JAK2 Antikörper

Produktnummer ABIN5541875

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch JAK2 in WB und EIA. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für JAK2 Antikörper (ABIN5541875)

Target: JAK2 (Janus Kinase 2 (JAK2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser JAK2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Produktdetails anti-JAK2 Antikörper

Spezifität: This antibody reacts with the 130 kDa JAK2 on human and other species with consensus sequence.

Aufreinigung: Protein G affinity

Immunogen: Synthetic peptide derived from the human JAK2 peptide, conjugated with KLH

Anwendungsinformationen

Applikationshinweise: ELISA: 1/64,000 for detection of the JAK2 peptide coated on ELISA plate. Western blot: 1/2,000 to detect 130 kDa JAK2 in TF-1 cell extract.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: 0.01M PBS, pH 7.4

Konservierungsmittel: Azide free

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store lyophilized at 2-8°C for 6 month or at -20°C long term. After reconstitution store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C long term. Avoid repeated freezing and thawing. Shelf life: one year from despatch.

Haltbarkeit: 12 months

Details zu JAK2

Target: JAK2 (Janus Kinase 2 (JAK2))

Andere Bezeichnung: tyrosine-protein kinase jak2

Hintergrund: Janus kinase 2 (JAK2) is a non-receptor tyrosine kinase that plays an important role in signal transduction through its association with receptors on the cell membrane. When these receptors are activated by extracellular signals, the receptors activate JAK2 which in turn phosphorylates the tyrosine residues on the receptors. The phosphorylation enables the binding of downstream signaling molecules, primarily, signal transducer and activator of transcription (STAT) proteins. STATs possess a SHdomain that specifically binds to phosphorylated tyrosine residue on the receptor. STAT in cytoplasma is activated after binding and migrates to nucleus to activate gene transcription. JAK2 mediates the transduction of a variety of extracellular signals in this pattern. The receptors that are associated with JAK2 include type II cytokine receptors, GM-CSF receptor family, gp130 receptor family, growth hormone receptor, prolactin receptor and EPO receptor.

UniProt: O60674

Pathways: JAK-STAT Signalweg, RTK Signalweg, Interferon-gamma Pathway, Positive Regulation of Peptide Hormone Secretion, Intracellular Steroid Hormone Receptor Signaling Pathway, Response to Growth Hormone Stimulus, Positive Regulation of Endopeptidase Activity, Protein targeting to Nucleus, CXCR4-mediated Signaling Events, Platelet-derived growth Factor Receptor Signaling, Unfolded Protein Response