DIABLO Antikörper (AA 56-239)

Produktnummer ABIN5541224

Dieser Maus Monoklonal Antikörper detektiert spezifisch DIABLO in WB und EIA. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für DIABLO Antikörper (AA 56-239) (ABIN5541224)

Target: DIABLO (Second Mitochondria-Derived Activator of Caspase (DIABLO))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser DIABLO Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Klon: AT19F2

Produktdetails anti-DIABLO Antikörper

Bindungsspezifität: AA 56-239

Aufreinigung: Protein-A affinity chromatography

Immunogen: Recombinant human SMAC/Diablo (56-239aa) purified from E. coli

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise: The antibody has been tested by ELISA, Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results.Recommended starting dilution is 1:3000.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS, pH 7.4 containing 0.02 % Sodium Azide and 10 % Glycerol

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store undiluted at 2-8°C for up to two weeks or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.

Haltbarkeit: 12 months

Details zu DIABLO

Target: DIABLO (Second Mitochondria-Derived Activator of Caspase (DIABLO))

Andere Bezeichnung: diablo,smac

Hintergrund: SMAC/Diablo is one of the proapoptotic proteins. SMAC promotes caspase activation in the cytochrome c/Apaf-1/caspase-9 pathway by binding to inhibitor of apoptosis proteins (IAPs) and removing their inhibitory activity. In healthy cells, SMAC is a mitochondrial protein, but when cells undergo apoptosis, SMAC is released into the cytosol. SMAC is ubiquitously expressed with highest expression in testis. Expression is also high in heart, liver, kidney, spleen, prostate and ovary. Low in brain, lung, thymus and peripheral blood leukocytes

UniProt: Q9NR28

Pathways: Apoptose, Caspase Kaskade in der Apoptose, Positive Regulation of Endopeptidase Activity