Caspase 6 Antikörper (N-Term)
Kurzübersicht für Caspase 6 Antikörper (N-Term) (ABIN5518670)
Target
Alle Caspase 6 (CASP6) Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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                                            Bindungsspezifität
- AA 7-27, N-Term
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                                            Verwendungszweck
- Anti-Caspase-6(P18)/CASP6 Antibody Picoband®
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                                            Sequenz
- FYRSREVLDP AEQYKMDHKR R
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                                            Kreuzreaktivität (Details)
- No cross-reactivity with other proteins
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                                            Produktmerkmale
- Anti-Caspase-6 (P18)/CASP6 Antibody (ABIN5518670). Tested in IHC, WB applications. This antibody reacts with Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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                                            Aufreinigung
- Immunogen affinity purified.
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                                            Immunogen
- A synthetic peptide corresponding to a sequence at the N-terminus of rat Caspase-6(P18), different from the related mouse sequence by two amino acids.
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                                            Isotyp
- IgG
 
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                                            Applikationshinweise
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                        Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Mouse, Rat 
 Immunohistochemistry (Frozen Section), 0.5-1 μg/mL, Rat, Mouse
 Western blot, 0.1-0.5 μg/mL, Mouse, Rat
 1. Fernandes-Alnemri, T., Litwack, G., Alnemri, E. S.Mch2, a new member of the apoptotic Ced-3/Ice cysteine protease gene family.Cancer Res. 55: 2737-2742, 1995. 2. Nikolaev, A., McLaughlin, T., O'Leary, D. D. M., Tessier-Lavigne, M.APP binds DR6 to trigger axon pruning and neuron death via distinct caspases Nature 457: 981-989, 2009. 3. Orth, K., Chinnaiyan, A. M., Garg, M., Froelich, C. J., Dixit, V. M.The CED-3/ICE-like protease Mch2 is activated during apoptosis and cleaves the death substrate lamin A.J. Biol. Chem. 271: 16443-16446, 1996.
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                                            Kommentare
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                        Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P) and IHC(F). 
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                                            Beschränkungen
- Nur für Forschungszwecke einsetzbar
 
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                                            Format
- Lyophilized
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                                            Rekonstitution
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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                                            Konzentration
- 500 μg/mL
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                                            Buffer
- Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.
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                                            Konservierungsmittel
- Sodium azide, Thimerosal (Merthiolate)
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                                            Vorsichtsmaßnahmen
- This product contains Thimerosal (Merthiolate) and Sodium azide: POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.
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                                            Lagerung
- 4 °C,-20 °C
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                                            Informationen zur Lagerung
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                        Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. 
 It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
 
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    - Caspase 6 (CASP6) (Caspase 6, Apoptosis-Related Cysteine Peptidase (CASP6))
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                                            Andere Bezeichnung
- CASP6
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                                            Hintergrund
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                        Synonyms: Caspase-6,CASP-6,3.4.22.59,Apoptotic protease Mch-2,Caspase-6 subunit p18,Caspase-6 subunit p11,Casp6,Mch2, Background: Caspase 6 is an enzyme that in humans is encoded by the caspase 6 gene. This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Using radiation hybrid mapping, the Caspase 6 gene is localized to human chromosome 4q25-q26. Caspase 6 functions as a downstream enzyme in the caspase activation cascade. And Caspase 6 can cleave lamin A to its signature apoptotic fragment. 
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                                            Molekulargewicht
- 35 kDa
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                                            UniProt
- O35397
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                                            Pathways
- Apoptose, Caspase Kaskade in der Apoptose
 Target
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