MCM6 Antikörper (Middle Region)

Produktnummer ABIN5517110

Produktdetails anti-MCM6 Antikörper

Target: MCM6 (Minichromosome Maintenance Complex Component 6 (MCM6))

Bindungsspezifität: Middle Region

Reaktivität: Human, Maus, Ratte, Hund, Rind (Kuh), Meerschweinchen, Pferd, Kaninchen, Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MCM6 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: CVAPTNPRFG GKELRDEEQT AESIKNQMTV KEWEKVFEMS QDKNLYHNLC

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 93%

Produktmerkmale: This is a rabbit polyclonal antibody against MCM6. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of Human MCM6

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu MCM6

Target: MCM6 (Minichromosome Maintenance Complex Component 6 (MCM6))

Andere Bezeichnung: MCM6 (MCM6 Produkte)

Synonyme: CG4039 antikoerper, DmMCM6 antikoerper, DmeMCM6 antikoerper, Dmel\\CG4039 antikoerper, MCM6 antikoerper, McM6 antikoerper, fs(1)K1214 antikoerper, mcm6 antikoerper, MCG40308 antikoerper, Mis5 antikoerper, P105MCM antikoerper, Mcmd6 antikoerper, mis5 antikoerper, mmcm6 antikoerper, ASP-l1 antikoerper, D1Wsu22e antikoerper, Minichromosome maintenance 6 antikoerper, DNA replication licensing factor MCM6 antikoerper, minichromosome maintenance complex component 6 antikoerper, minichromosome maintenance complex component 6 L homeolog antikoerper, DNA replication licensing factor mcm-6 antikoerper, Mcm6 antikoerper, TP02_0113 antikoerper, PVX_114735 antikoerper, CMU_027970 antikoerper, MCM6 antikoerper, mcm6.L antikoerper, mcm-6 antikoerper

Hintergrund: The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of the complex by CDC2 kinase reduces the helicase activity, suggesting a role in the regulation of DNA replication. Single nucleotide polymorphisms in the intron regions of this gene are associated with differential transcriptional activation of the promoter of the neighboring lactase gene and, thereby, influence lactose intolerance in early adulthood.

Alias Symbols: MCM6,

Protein Interaction Partner: MCM10, HUWE1, SNRPB2, MCM2, NUDT2, ZBTB9, FAM161A, UBC, SUMO2, SUMO3, MCMBP, POLK, MCM4, MCM3, KPNA3, HSP90AB1, CDKN2A, ACLY, CAP1, ING5, MCM6, BAG3, TONSL, MMS22L, ASF1B, SMC1A, MCM7, CCNA1, VCAM1, ITGA4, FN1, gag-pol, GMNN, ORC6, DBF4, CDC7, PAXIP1, TP5

Protein Size: 821

Gen-ID: 4175

UniProt: Q14566

Pathways: DNA Reparatur, Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA