Growth Hormone Receptor Antikörper (N-Term)

Produktnummer ABIN5514835

Der Kaninchen Polyklonal anti-Growth Hormone Receptor Antikörper wird verwendet zum Nachweis von Growth Hormone Receptor in Proben von Human und Pferd. Er wurde validiert für WB.

Kurzübersicht für Growth Hormone Receptor Antikörper (N-Term) (ABIN5514835)

Target: Growth Hormone Receptor (GHR)

Reaktivität: Human, Pferd

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Growth Hormone Receptor Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-Growth Hormone Receptor Antikörper

Bindungsspezifität: N-Term

Verwendungszweck: GHR Antibody - N-terminal region

Sequenz: LLTLALAGSS DAFSGSEATA AILSRAPWSL QSVNPGLKTN SSKEPKFTKC

Homologie: Horse: 83%, Human: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against GHR. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Human GHR

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP44229-100UG

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Details zu Growth Hormone Receptor

Target: Growth Hormone Receptor (GHR)

Andere Bezeichnung: GHR

Hintergrund:

Background Information: This gene encodes a member of the type I cytokine receptor family, which is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature. In humans and rabbits, but not rodents, growth hormone binding protein (GHBP) is generated by proteolytic cleavage of the extracellular ligand-binding domain from the mature growth hormone receptor protein. Multiple alternatively spliced transcript variants have been found for this gene.

Gene Name: growth hormone receptor

Alternative Symbols: GHBP, GHIP

Protein Name: Growth hormone receptor

Molekulargewicht: 32kDa

Gen-ID: 2690

UniProt: P10912

Pathways: NF-kappaB Signalweg, JAK-STAT Signalweg, Response to Growth Hormone Stimulus