Complement Factor B Antikörper (N-Term)

Produktnummer ABIN5514558

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch Complement Factor B in WB. Es zeigt Reaktivität gegenüber Proben von Human, Ratte, Maus, Rind (Kuh), Hund, Meerschweinchen, Pferd, Kaninchen und Schaf.

Kurzübersicht für Complement Factor B Antikörper (N-Term) (ABIN5514558)

Target: Complement Factor B (CFB)

Reaktivität: Human, Ratte, Maus, Rind (Kuh), Hund, Meerschweinchen, Pferd, Kaninchen, Schaf

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Complement Factor B Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-Complement Factor B Antikörper

Bindungsspezifität: N-Term

Verwendungszweck: CFB Antibody - N-terminal region

Sequenz: NGAGYCSNPG IPIGTRKVGS QYRLEDSVTY HCSRGLTLRG SQRRTCQEGG

Homologie: Cow: 93%, Dog: 86%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 100%, Rabbit: 86%, Rat: 100%, Sheep: 93%

Produktmerkmale: This is a rabbit polyclonal antibody against CFAB. It was validated on Western Blot.

Aufreinigung: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Human CFAB

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP56331-100UG

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Details zu Complement Factor B

Target: Complement Factor B (CFB)

Andere Bezeichnung: CFB

Hintergrund:

Background Information: This gene encodes complement factor B, a component of the alternative pathway of complement activation. Factor B circulates in the blood as a single chain polypeptide. Upon activation of the alternative pathway, it is cleaved by complement factor D yielding the noncatalytic chain Ba and the catalytic subunit Bb. The active subunit Bb is a serine protease which associates with C3b to form the alternative pathway C3 convertase. Bb is involved in the proliferation of preactivated B lymphocytes, while Ba inhibits their proliferation. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. This cluster includes several genes involved in regulation of the immune reaction. Polymorphisms in this gene are associated with a reduced risk of age-related macular degeneration. The polyadenylation site of this gene is 421 bp from the 5' end of the gene for complement component 2.

Gene Name: complement factor B

Alternative Symbols: BF, FB, BFD, GBG, CFAB, CFBD, PBF2, AHUS4, FBI12, H2-Bf, ARMD14

Protein Name: complement factor B

Molekulargewicht: 84kDa

Gen-ID: 629

NCBI Accession: NP_001701

UniProt: P00751

Pathways: Komplementsystem, Proton Transport, Ribonucleoside Biosynthetic Process