14-3-3 sigma/SFN Antikörper
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- Target Alle 14-3-3 sigma/SFN (SFN) Antikörper anzeigen
- 14-3-3 sigma/SFN (SFN) (Stratifin (SFN))
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Reaktivität
- Human
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser 14-3-3 sigma/SFN Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), Immunohistochemistry (IHC)
- Aufreinigung
- Protein A Chromatography
- Immunogen
- Full length recombinant 14-3-3 sigma protein was used as the immunogen for this antibody.
- Isotyp
- IgG
- Top Product
- Discover our top product SFN Primärantikörper
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anti-Stratifin (SFN) antibody
SFN Reaktivität: Human WB, IF, IP, IHC (p), ICC Wirt: Kaninchen Polyclonal unconjugated
anti-Stratifin (SFN) (AA 1-248) antibodySFN Reaktivität: Human WB, ELISA, IP, IHC (p) Wirt: Maus Monoclonal 3C3 unconjugated
anti-Stratifin (SFN) (C-Term) antibodySFN Reaktivität: Human WB, IF, IHC (p), ICC Wirt: Kaninchen Polyclonal unconjugated
anti-Stratifin (SFN) (Internal Region) antibodyVerified SFN Reaktivität: Human, Maus, Ratte WB, IHC, ELISA Wirt: Ziege Polyclonal unconjugated
anti-Stratifin (SFN) (AA 140-156) antibodySFN Reaktivität: Human, Maus, Ratte WB, IHC (p), ICC Wirt: Kaninchen Polyclonal unconjugated
anti-Stratifin (SFN) (AA 1-248) antibodySFN Reaktivität: Human WB, IHC, IP, ICC Wirt: Kaninchen Polyclonal unconjugated
anti-Stratifin (SFN) (AA 222-248), (C-Term) antibodySFN Reaktivität: Human WB, IF, IHC (p), FACS Wirt: Kaninchen Polyclonal RB27523 unconjugated
anti-Stratifin (SFN) (AA 1-248) antibodySFN Reaktivität: Human WB, ELISA, IF Wirt: Maus Monoclonal 2G2 unconjugated
anti-Stratifin (SFN) antibodySFN Reaktivität: Human WB, IHC, StM Wirt: Maus Monoclonal CPTC-SFN-2 unconjugated
anti-Stratifin (SFN) (AA 1-249) antibodySFN Reaktivität: Human WB, IHC, IHC (p) Wirt: Maus Monoclonal 3C3 unconjugated
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- Applikationshinweise
- WB: 1-3 μg/mL, IHC: 10 μg/mL
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Konzentration
- 0.5 mg/mL
- Buffer
- PBS containing 0.05 % BSA, PH 7.4
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- 4 °C/-20 °C
- Informationen zur Lagerung
- Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
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- Target
- 14-3-3 sigma/SFN (SFN) (Stratifin (SFN))
- Andere Bezeichnung
- 14-3-3 sigma (SFN Produkte)
- Hintergrund
- 14-3-3 sigma is a member of a highly conserved family of 14-3-3 proteins that are present in all eukaryotic organisms. There are 7 known human 14-3-3 isotypes and they play important roles in many biological activities by binding to and altering the subcellular localization and/or stability of key molecules in various signaling cascades. 14-3-3 sigma was originally characterized as a human mammary epithelium marker 1 and later rediscovered as an important molecule for cell cycle checkpoint regulation. Recently it has been reported that 14-3-3 sigma may serve as a prognosis marker predicting survival of pancreatic cancer patient treatment. 14-3-3 is the only 14-3-3 isoform induced by the tumor suppressor protein p53, in response to -irradiation and other DNA-damaging agents. 14-3-3 is a p53-regulated inhibitor of G2/M progression and acts as a tumor suppressor gene that is inactivated by methylation of its 5' CpG islands in epithelial tumor cells. Two isoforms of the human proteins are produced by alternative splicing.
- Molekulargewicht
- 32 kDa
- Gen-ID
- 2810
- UniProt
- P31947
- Pathways
- p53 Signalweg, Myometrial Relaxation and Contraction
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