DEPTOR Antikörper (AA 111-301)

Produktnummer ABIN5027150

Produktdetails anti-DEPTOR Antikörper

Target: DEPTOR (DEP Domain Containing mTOR-Interacting Protein (DEPTOR))

Bindungsspezifität: AA 111-301

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DEPTOR Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Aufreinigung: Protein A Chromatography

Immunogen: A partial length recombinant DEPTOR protein (amino acids 111-301) was used as the immunogen for this antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 2-4 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: PBS containing 0.05 % BSA, PH 7.4

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Details zu DEPTOR

Target: DEPTOR (DEP Domain Containing mTOR-Interacting Protein (DEPTOR))

Andere Bezeichnung: DEPTOR/DEPDC6 (DEPTOR Produkte)

Synonyme: DEP.6 antikoerper, DEPDC6 antikoerper, 4731402B04Rik antikoerper, 9130412E02Rik antikoerper, D15Ertd336e antikoerper, D15Ertd597e antikoerper, Depdc6 antikoerper, Depdc6-001 antikoerper, Depdc6-002 antikoerper, R75183 antikoerper, mKIAA4200 antikoerper, RGD1561030 antikoerper, RAPGEF4 antikoerper, DEP domain containing MTOR interacting protein antikoerper, DEP domain containing MTOR-interacting protein antikoerper, DEPTOR antikoerper, Deptor antikoerper

Hintergrund: DEPTOR is an mTOR inhibitor whose expression is negatively regulated by mTOR. DEPTOR expression is required to maintain PI3K and Akt activation and to inhibit apoptosis. DEPTOR is expressed in different microvascular ECs (endothelial cells). It plays a key role in maintaining stem cell pluripotency by limiting mTOR activity in undifferentiated embryonic stem cells (ESCs). It is overexpressed in RPMI-8226 human multiple myeloma cells, and plays an important role in maintaining cell survival.

Molekulargewicht: 46 kDa

Gen-ID: 64798

UniProt: Q8TB45

Pathways: PI3K-Akt Signalweg, RTK Signalweg, Regulation of Cell Size, BCR Signaling, Warburg Effekt