MAVS Antikörper (N-Term)

Produktnummer ABIN501118

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch MAVS in WB, IF, IHC (p) und EIA. Er zeigt eine Reaktivität gegenüber Human, Maus und Ratte.

Kurzübersicht für MAVS Antikörper (N-Term) (ABIN501118)

Target: MAVS (Mitochondrial Antiviral Signaling Protein (MAVS))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MAVS Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Produktdetails anti-MAVS Antikörper

Bindungsspezifität: N-Term

Spezifität: This antibody detects MAVS at N-term.

Kreuzreaktivität (Details): Species reactivity (tested):Human, Mouse, Rat.

Aufreinigung: Affinity chromatography

Immunogen: VISA antibody was raised against a 13 amino acid peptide from near the amino terminus of human VISA.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA. Western blot. Immunohistochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS, 0.02 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Details zu MAVS

Target: MAVS (Mitochondrial Antiviral Signaling Protein (MAVS))

Andere Bezeichnung: MAVS

Hintergrund: Two distinct signaling pathways activate the host innate immunity against viral infection. One pathway is reliant on members of the Toll-like receptor (TLR) family while the other uses the RNA helicase RIG-I as a receptor for intracellular viral double-stranded RNA as a trigger for the immune response. VISA is a mitochondrial membrane protein that was identified as a critical component in the IFN-b signaling pathways that recruits IRF-3 to RIG-I, leading to its activation and that of NF-kappaB. VISA is also thought to interact with other components of the innate immune pathway such as the TLR adapter protein TRIF, TRAF2 and TRAF6. VISA also interacts with the IKKalpha, IKKbeta and IKKepsilon kinases through its C-terminal region. Cleavage of this region by the Hepatitis C virus (HCV) protease allows HCV to escape the host immune system. At least three isoforms of VISA are known to exist.Synonyms: CARD adapter inducing interferon-beta, Cardif, IPS1, Mitochondrial antiviral-signaling protein, Mitochondrial antiviral-signaling protein, Putative NF-kappa-B-activating protein 031N, VISA, Virus-induced-signaling adapter, nterferon-beta promoter stimulator protein 1

Gen-ID: 57506

NCBI Accession: NP_065797

Pathways: Activation of Innate immune Response, Inositol Metabolic Process, Hepatitis C