CDCA8 Antikörper (N-Term)

Produktnummer ABIN499603

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch CDCA8 in WB, IF und EIA. Er zeigt eine Reaktivität gegenüber Human, Maus und Ratte.

Kurzübersicht für CDCA8 Antikörper (N-Term) (ABIN499603)

Target: CDCA8 (Cell Division Cycle Associated 8 (CDCA8))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CDCA8 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Produktdetails anti-CDCA8 Antikörper

Bindungsspezifität: N-Term

Spezifität: This antibody reacts to CDCA8.

Aufreinigung: Affinity chromatography purified via peptide column

Immunogen: CDCA8 antibody was raised against a 19 amino acid peptide near the amino terminus of the human CDCA8.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA. Western Blot: CDCA8 antibody can be used for detection of CDCA8 at 1 μg/mL. Immunofluorescence.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C.

Details zu CDCA8

Target: CDCA8 (Cell Division Cycle Associated 8 (CDCA8))

Andere Bezeichnung: CDCA8 / Borealin

Hintergrund: CDCA8 is a component of a chromosomal passenger complex (CPC) required for stability of the bipolar mitotic spindle. The chromosomal passenger complex, which includes Survivin, CDCA8, INCENP and Aurora-B, is known to play crucial roles during mitosis and cell division. It was found that CDCA8 interacting with Aurora-B, INCENP and Survivin, increases during G2/M phase and then reduces after exit from M phase. CDCA8 is cell cycle regulated, down-regulated in response to p53/Rb-signaling, and up-regulated in many types of cancerous tissues. In Drosophila cells, inactivation of CDCA8 results in polyploidy, delayed mitosis and abnormal tissue development, indicating its critical role for cell proliferation. Recent studies show that CDCA8 is essential for cell proliferation during early embryonic development, and its early embryonic lethality cannot be rescued by the loss of p53. Its aberrant expression is linked to a poor prognosis for gastric cancer.Synonyms: Cell division cycle-associated protein 8, Dasra-B, PESCRG3, Pluripotent embryonic stem cell-related gene 3 protein, hDasra-B

Gen-ID: 55143

NCBI Accession: NP_060571

UniProt: Q53HL2

Pathways: Zellzyklus, M Phase