Caspase 6 Antikörper (N-Term)

Produktnummer ABIN499571

Der Kaninchen Polyklonal Anti-Caspase 6-Antikörper wurde für WB, IF und EIA validiert. Er ist geeignet, Caspase 6 in Proben von Human zu detektieren.

Kurzübersicht für Caspase 6 Antikörper (N-Term) (ABIN499571)

Target: Caspase 6 (CASP6) (Caspase 6, Apoptosis-Related Cysteine Peptidase (CASP6))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Caspase 6 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Produktdetails anti-Caspase 6 Antikörper

Bindungsspezifität: N-Term

Spezifität: Caspase-6 antibody was raised against a 15 amino acid peptide from near the amino-terminus of human Caspase-6.

Aufreinigung: Affinity chromatography purified via peptide column

Immunogen: Virus Casp-6 / Mch2 (N-Terminus) Peptide

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA. Western Blot: Caspase-6 antibody can be used for the detection of caspase-6 at 0.5 μg/mL. Depending on cell lines or tissues used, either full-length or other cleavage products maybe observed. Immunocytochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C.

Details zu Caspase 6

Target: Caspase 6 (CASP6) (Caspase 6, Apoptosis-Related Cysteine Peptidase (CASP6))

Andere Bezeichnung: Caspase-6

Hintergrund: Caspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens (reviewed in 1 and 2). The apoptotic subfamily can be further divided into initiator caspases, which are activated in response to death signals, and executioner caspases, which are activated by the initiator caspases and are responsible for cleavage of cellular substrates that ultimately lead to cell death (reviewed in 3). Caspase-6 is an executioner caspase that was idientifed based on its homology with human caspases 2 and 3 as well as the C. elegans cell death protein CED-3 (4). It possesses two isoforms, of which only the longer form possesses protease activity (4). Caspase-6 is highly expressed in adult brain and may play a role in several neuronal pathologies (5).Synonyms: Apoptotic protease Mch-2, CASP-6, CASP6, MCH-2, MCH2

Gen-ID: 839

NCBI Accession: NP_001217

UniProt: P55212

Pathways: Apoptose, Caspase Kaskade in der Apoptose