POLD1 Antikörper

Produktnummer ABIN499061

Der Kaninchen Polyklonal anti-POLD1 Antikörper wird verwendet zum Nachweis von POLD1 in Proben von Human, Ratte und Maus. Er wurde validiert für WB.

Kurzübersicht für POLD1 Antikörper (ABIN499061)

Target: POLD1 (Polymerase (DNA Directed), delta 1, Catalytic Subunit 125kDa (POLD1))

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser POLD1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-POLD1 Antikörper

Spezifität: This antibody detects endogenous levels of CNA pol delta cat protein. (region surrounding Asp1091)

Kreuzreaktivität (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Aufreinigung: Affinity-Chromatography using epitope-specific immunogen

Anwendungsinformationen

Applikationshinweise: Western blot: 1: 500-1: 1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.2, 0.05 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu POLD1

Target: POLD1 (Polymerase (DNA Directed), delta 1, Catalytic Subunit 125kDa (POLD1))

Andere Bezeichnung: POLD1

Hintergrund: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II, and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2F/RPB6 is part of the clamp element and togther with parts of RPB1 and RPB2 forms a pocket to which the RPB4-RPB7 subcomplex binds (By similarity).Synonyms: DNA polymerase delta catalytic subunit, DNA polymerase subunit delta p125

Molekulargewicht: approx. 125 kDa

Gen-ID: 5424

NCBI Accession: NP_002682

UniProt: P28340

Pathways: Telomere Maintenance, DNA Reparatur, DNA Replication, Chromatin Binding, Synthesis of DNA