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RPS6KB1 Antikörper (pSer447)
RPS6KB1
Reaktivität: Human, Maus, Ratte
WB, IHC (p)
Wirt: Kaninchen
Polyclonal
unconjugated
Produktdetails anti-RPS6KB1 Antikörper
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Target
Alle RPS6KB1 Antikörper anzeigen
RPS6KB1
(Ribosomal Protein S6 Kinase, 70kDa, Polypeptide 1 (RPS6KB1))
Bindungsspezifität
Alle Epitope für RPS6KB1 Antikörper
pSer447
Reaktivität
Alle Reaktivitäten für RPS6KB1 Antikörper
Human, Maus, Ratte
Wirt
Alle Wirte für RPS6KB1 Antikörper
Kaninchen
Klonalität
Alle Klonalitäten für RPS6KB1 Antikörper
Polyklonal
Konjugat
Alle Konjugate für RPS6KB1 Antikörper
Dieser RPS6KB1 Antikörper ist unkonjugiert
Applikation
Alle Applikationen für RPS6KB1 Antikörper
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Spezifität
This antibody detects endogenous levels of p70 S6 kinase alpha protein only when phosphorylated at Ser424.
Kreuzreaktivität (Details)
Species reactivity (expected):Mouse and Rat. Species reactivity (tested):Human.
Aufreinigung
Affinity chromatography
Reinheit
> 95 % by SDS-PAGE
Top Product
Discover our top product RPS6KB1 Primärantikörper
Alternativen
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anti-Ribosomal Protein S6 Kinase, 70kDa, Polypeptide 1 (RPS6KB1) (pThr389), (pThr412) antibody
RPS6KB1
Reaktivität: Human, Maus, Ratte, Schwein
WB, IHC, ELISA, IF, ICC
Wirt: Kaninchen
Polyclonal
unconjugated
Anwendungsinformationen
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Applikationshinweise
Western Blot: 1/500 - 1/1000. Immunohistochemistry: 1/50 - 1/200. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Beschränkungen
Nur für Forschungszwecke einsetzbar
Handhabung
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Konzentration
1,0 mg/mL
Buffer
Phosphate buffered saline (PBS), pH 7.2., 0.09 % sodium azide, 50 % glycerol
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung
Avoid repeated freezing and thawing.
Lagerung
4 °C/-20 °C
Informationen zur Lagerung
Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Details zu RPS6KB1
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Target
RPS6KB1
(Ribosomal Protein S6 Kinase, 70kDa, Polypeptide 1 (RPS6KB1))
Andere Bezeichnung
RPS6KB1 / STK14A (RPS6KB1 Produkte )
Synonyme
PS6K antikoerper, S6K antikoerper, S6K-beta-1 antikoerper, S6K1 antikoerper, STK14A antikoerper, p70 S6KA antikoerper, p70(S6K)-alpha antikoerper, p70-S6K antikoerper, p70-alpha antikoerper, 10539 antikoerper, 7084 antikoerper, CG10539 antikoerper, DS6K antikoerper, Dmel\\CG10539 antikoerper, Dp70S6k antikoerper, Dp70[s6k] antikoerper, Dp70s6k antikoerper, S6k antikoerper, dS6K antikoerper, dS6k antikoerper, dp70[S6k] antikoerper, dp70s6k antikoerper, dps6k antikoerper, ds6k antikoerper, fs(3)07084 antikoerper, l(3)07084 antikoerper, p70 S6K antikoerper, p70/S6K antikoerper, p70S6K antikoerper, p70[S6 kinase] antikoerper, p70[S6K] antikoerper, p70[S6k] antikoerper, p70[S6kinase] antikoerper, p70s6K antikoerper, s6k antikoerper, s6k11 antikoerper, 2610318I15Rik antikoerper, 4732464A07Rik antikoerper, 70kDa antikoerper, AA959758 antikoerper, AI256796 antikoerper, AI314060 antikoerper, p70/85s6k antikoerper, p70s6k antikoerper, p70s6k-A antikoerper, p70-s6k antikoerper, ps6k antikoerper, rps6kb1 antikoerper, rps6kb1-A antikoerper, s6K1 antikoerper, stk14a antikoerper, fc51h01 antikoerper, wu:fc51h01 antikoerper, zgc:55713 antikoerper, ribosomal protein S6 kinase B1 antikoerper, Ribosomal protein S6 kinase antikoerper, ribosomal protein S6 kinase, polypeptide 1 antikoerper, ribosomal protein S6 kinase B1 L homeolog antikoerper, ribosomal protein S6 kinase B1 S homeolog antikoerper, ribosomal protein S6 kinase b, polypeptide 1b antikoerper, RPS6KB1 antikoerper, S6k antikoerper, Rps6kb1 antikoerper, rps6kb1.L antikoerper, rps6kb1.S antikoerper, rps6kb1b antikoerper
Hintergrund
P70 S6 kinase is a mitogen activated Ser/Thr protein kinase that is required for cell growth and G1 cell cycle progression. p70 S6 kinase phosphorylates the S6 protein of the 40S ribosomal subunit and is involved in translational control of 5' oligopyrimidine tract mRNAs. A second isoform, p85 S6 kinase, is derived from the same gene and is identical to p70 S6 kinase except for 23 extra residues at the amino terminus, which encode a nuclear localizing signal.Ser411, Thr421 and Ser424 lie within a Ser-Pro-rich region located in the pseudosubstrate region. Phosphorylation at these sites is thought to activate p70 S6 kinase via relief of pseudosubstrate suppression. Another LY294002 and rapamycin sensitive phosphorylation site, Ser371, is an in vitro substrate for mTOR and correlates well with the activity of a partially rapamycin resistant mutant p70 S6 kinase.Synonyms: 70 kDa ribosomal protein S6 kinase 1, Ribosomal protein S6 kinase I, Ribosomal protein S6 kinase beta-1, S6K-beta-1, S6K1, Serine/threonine-protein kinase 14A, p70 S6 kinase alpha, p70 S6K-alpha, p70 S6KA, p70-S6K 1
Molekulargewicht
approx. 59,70,85 kDa
Gen-ID
6198
NCBI Accession
NP_003152
UniProt
P23443
Pathways
PI3K-Akt Signalweg , RTK Signalweg , AMPK Signaling , Regulation of Cell Size , Skeletal Muscle Fiber Development , Feeding Behaviour , G-protein mediated Events , Smooth Muscle Cell Migration , Interaction of EGFR with phospholipase C-gamma , Warburg Effekt
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