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PIK3CA Antikörper
PIK3CA
Reaktivität: Human, Maus
WB, IHC (p)
Wirt: Kaninchen
Polyclonal
unconjugated
Produktdetails anti-PIK3CA Antikörper
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Target
Alle PIK3CA Antikörper anzeigen
PIK3CA
(Phosphoinositide-3-Kinase, Catalytic, alpha Polypeptide (PIK3CA))
Reaktivität
Alle Reaktivitäten für PIK3CA Antikörper
Human, Maus
Wirt
Alle Wirte für PIK3CA Antikörper
Kaninchen
Klonalität
Alle Klonalitäten für PIK3CA Antikörper
Polyklonal
Konjugat
Alle Konjugate für PIK3CA Antikörper
Dieser PIK3CA Antikörper ist unkonjugiert
Applikation
Alle Applikationen für PIK3CA Antikörper
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Spezifität
This antibody detects endogenous levels of PI 3-kinase p110alpha protein. (region surrounding Arg519)
Kreuzreaktivität (Details)
Species reactivity (tested):Human, Mouse.
Aufreinigung
Affinity chromatography
Reinheit
> 95 % by SDS-PAGE
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Discover our top product PIK3CA Primärantikörper
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anti-Phosphoinositide-3-Kinase, Catalytic, alpha Polypeptide (PIK3CA) (AA 961-1068) antibody
PIK3CA
Reaktivität: Human, Maus, Ratte, Rind (Kuh), Kaninchen
WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro), ICC
Wirt: Kaninchen
Polyclonal
unconjugated
Anwendungsinformationen
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Applikationshinweise
Immunohistochemistry: 1/50 - 1/200. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Beschränkungen
Nur für Forschungszwecke einsetzbar
Handhabung
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Konzentration
1,0 mg/mL
Buffer
Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung
Avoid repeated freezing and thawing.
Lagerung
4 °C/-20 °C
Informationen zur Lagerung
Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Details zu PIK3CA
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Target
PIK3CA
(Phosphoinositide-3-Kinase, Catalytic, alpha Polypeptide (PIK3CA))
Andere Bezeichnung
PIK3CA (PIK3CA Produkte )
Synonyme
CLOVE antikoerper, CWS5 antikoerper, MCAP antikoerper, MCM antikoerper, MCMTC antikoerper, PI3K antikoerper, p110-alpha antikoerper, C-P3K antikoerper, PI3-kinase antikoerper, PI3K-alpha antikoerper, pi3-k antikoerper, pi3k antikoerper, AA414921 antikoerper, C530050K14 antikoerper, p50alpha antikoerper, p55alpha antikoerper, p85alpha antikoerper, 6330412C24Rik antikoerper, caPI3K antikoerper, p110 antikoerper, p110alpha antikoerper, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha antikoerper, Phosphoinositide-3-kinase, catalytic, alpha polypeptide antikoerper, phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha antikoerper, phosphoinositide-3-kinase regulatory subunit 1 antikoerper, PIK3CA antikoerper, GL50803_14855 antikoerper, pik3ca antikoerper, Pik3ca antikoerper, Pik3r1 antikoerper
Hintergrund
Phosphatidylinositol 3-kinase (PI 3-kinase) is composed of 85 kDa (p85) and 110 kDa (p110) subunits. p85 lacks PI 3-kinase activity and acts as an adapter, coupling p110 to activated protein tyrosine kinase. Two forms of p85 have been described (p85alpha and p85beta), each possessing one SH3 and two SH2 domains. Various p110 isoforms have been identified. p110alpha and p110beta interact with p85alpha, and p110alpha has also been shown to interact with p85beta in vitro. p110delta expression is restricted to white blood cells. It has been shown to bind p85alpha and beta, but it apparently does not phosphorylate these subunits. p110delta seems to have the capacity to autophosphorylate. p110gamma does not interact with the p85 subunits. It has been shown to be activated by alpha and beta-gamma heterotrimeric G proteins.Synonyms: 5-bisphosphate 3-kinase catalytic subunit alpha isoform, EC=2.7.1.153, PI3-kinase p110 subunit alpha, PI3K, PIK3CA, Phosphatidylinositol-4, PtdIns-3-kinase p110
Molekulargewicht
approx. 110 kDa
Gen-ID
5290
NCBI Accession
NP_006209
UniProt
P42336
Pathways
PI3K-Akt Signalweg , RTK Signalweg , T-Zell Rezeptor Signalweg , AMPK Signaling , Interferon-gamma Pathway , TLR Signalweg , Fc-epsilon Rezeptor Signalübertragung , EGFR Signaling Pathway , Neurotrophin Signalübertragung , Inositol Metabolic Process , Hepatitis C , CXCR4-mediated Signaling Events , Signaling Events mediated by VEGFR1 and VEGFR2 , Signaling of Hepatocyte Growth Factor Receptor , VEGFR1 Specific Signals , VEGF Signaling
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