RASGRF1 Antikörper
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- Target Alle RASGRF1 Antikörper anzeigen
- RASGRF1 (Ras Protein-Specific Guanine Nucleotide-Releasing Factor 1 (RASGRF1))
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Reaktivität
- Maus, Ratte
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser RASGRF1 Antikörper ist unkonjugiert
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Applikation
- Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Spezifität
- This antibody detects endogenous levels of Ras-GRF1 protein.
- Kreuzreaktivität (Details)
- Species reactivity (tested):Mouse and Rat.
- Aufreinigung
- Affinity chromatography using epitope-specific immunogen
- Reinheit
- > 95 % (by SDS-PAGE)
- Top Product
- Discover our top product RASGRF1 Primärantikörper
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- Applikationshinweise
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Immunohistochemistry on paraffin sections: 1: 50 - 1: 200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Konzentration
- 1.0 mg/mL
- Buffer
- Phosphate buffered saline (PBS) with 0.05 % sodium azide, approx. pH 7.2
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- Avoid repeated freezing and thawing.
- Lagerung
- 4 °C/-20 °C
- Informationen zur Lagerung
- Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
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- Target
- RASGRF1 (Ras Protein-Specific Guanine Nucleotide-Releasing Factor 1 (RASGRF1))
- Andere Bezeichnung
- RASGRF1 (RASGRF1 Produkte)
- Synonyme
- CDC25 antikoerper, CDC25L antikoerper, GNRP antikoerper, GRF1 antikoerper, GRF55 antikoerper, H-GRF55 antikoerper, PP13187 antikoerper, ras-GRF1 antikoerper, AI844718 antikoerper, CDC25Mm antikoerper, Grf1 antikoerper, Grfbeta antikoerper, P190-A antikoerper, Ras-GRF1 antikoerper, p190 antikoerper, p190RhoGEF antikoerper, cdc25 antikoerper, rasgrf1 antikoerper, Ras protein specific guanine nucleotide releasing factor 1 antikoerper, RAS protein-specific guanine nucleotide-releasing factor 1 antikoerper, Ras protein specific guanine nucleotide releasing factor 1 S homeolog antikoerper, si:ch211-234p18.3 antikoerper, RASGRF1 antikoerper, Rasgrf1 antikoerper, rasgrf1.S antikoerper, si:ch211-234p18.3 antikoerper, rasgrf1 antikoerper
- Hintergrund
- A critical step in signal transduction responses to stimulation of cell surface receptors by their ligands involves the accumulation of Ras proteins in their active GTP-bound state. To reach their active GTP-bound state, Ras proteins must first release bound GDP, a rate limiting step mediated by a guanine nucleotide releasing factor (GRF). The mammalian Ras p21 GRF protein has been designated Ras-GRF1 p140. Ras-GRF1 accelerates release of GDP from H- and N-Ras p21 protein in vitro, but not from the related Ral A or Cdc42Hs GTP-binding proteins. Of interest, a region mapping within the amino terminal domain of Ras-GRF1 is similar to both the human breakpoint cluster protein, Bcr, and the Dbl proto-oncogene product, a guanine nucleotide-releasing factor for Cdc42Hs. Ras-GRF2 p135 has also been identified. Ras-GRF2 p135 is highly homologous to Ras-GRF1 p140 except in the region between the REM and CDC25 domains and appears to function similarly to Ras-GRF1 p140.Synonyms: CDC25, GNRP, GRF1, Guanine nucleotide-releasing protein, Ras-GRF1, Ras-specific guanine nucleotide-releasing factor 1, Ras-specific nucleotide exchange factor CDC25
- Gen-ID
- 19417
- NCBI Accession
- NP_035375
- UniProt
- P27671
- Pathways
- RTK Signalweg, Zellzyklus, M Phase
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