TICAM1 Antikörper (AA 115-143)

Produktnummer ABIN3029184

Der Kaninchen Polyklonal anti-TICAM1 Antikörper (ABIN3029184) detektiert spezifisch TICAM1 in WB und ELISA. Dieser Antikörper reagiert spezifisch mit Proben aus Human und Maus.

Kurzübersicht für TICAM1 Antikörper (AA 115-143) (ABIN3029184)

Target: TICAM1 (Toll-Like Receptor Adaptor Molecule 1 (TICAM1))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TICAM1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-TICAM1 Antikörper

Bindungsspezifität: AA 115-143

Verwendungszweck: TICAM1 Antibody

Aufreinigung: Antigen affinity

Immunogen: A portion of amino acids 115-143 from the human protein was used as the immunogen for this TICAM1 antibody.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Titration of the TICAM1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the TICAM1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Details zu TICAM1

Target: TICAM1 (Toll-Like Receptor Adaptor Molecule 1 (TICAM1))

Andere Bezeichnung: TICAM1

Hintergrund: Involved in innate immunity against invading pathogens. Adapter used by< a href=../search_result.php?search_txt=TLR>TLR3and< a href=../search_result.php?search_txt=TLR>TLR4(through TICAM2) to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TRIF recruitment through its TIR domain. Distinct protein-interaction motifs allow recruitment of the effector proteins< a href=../search_result.php?search_txt=Tbk1>TBK1, TRAF6 and< a href=../search_result.php?search_txt=ripk>RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7,< a href=../search_result.php?search_txt=nf-kb>NF-kappa-Band FADD respectively.

UniProt: Q8IUC6

Pathways: TLR Signalweg, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Hepatitis C, Toll-Like Receptors Cascades