CD40 Antikörper (AA 247-276)

Produktnummer ABIN3030395

Der Kaninchen Polyklonal Anti-CD40-Antikörper wurde für WB und ELISA validiert. Er ist geeignet, CD40 in Proben von Human zu detektieren.

Kurzübersicht für CD40 Antikörper (AA 247-276) (ABIN3030395)

Target: CD40

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CD40 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-CD40 Antikörper

Bindungsspezifität: AA 247-276

Kreuzreaktivität (Details): Expected species reactivity: Mouse, Pig

Aufreinigung: Antigen affinity purified

Immunogen: A portion of amino acids 247-276 from the human protein was used as the immunogen for this CD40 antibody.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Titration of the CD40 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the CD40 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Details zu CD40

Target: CD40

Andere Bezeichnung: CD40

Hintergrund: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been found to be essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

UniProt: P25942

Pathways: NF-kappaB Signalweg, Cellular Response to Molecule of Bacterial Origin, M Phase, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Cancer Immune Checkpoints