AMACR
Reaktivität: Human
IHC, StM
Wirt: Kaninchen
Polyclonal
unconjugated
Applikationshinweise
Optimal dilution of the AMACR antibody should be determined by the researcher.\. Immunohistology (FFPE): 1-2 μg/mL for 30 minutes at RT,IF: 1-2 μg/mL
Beschränkungen
Nur für Forschungszwecke einsetzbar
Konzentration
1 mg/mL
Buffer
1 mg/mL in sterile PBS, BSA free, sodium azide free
Konservierungsmittel
Azide free
Lagerung
4 °C,-20 °C
Informationen zur Lagerung
Store the AMACR antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).
Target
AMACR
(alpha-Methylacyl-CoA Racemase (AMACR))
Andere Bezeichnung
AMACR / p504S
Hintergrund
AMACR, also known as p504S is an enzyme that is involved in bile acid biosynthesis and beta-oxidation of branched-chain fatty acids. It is expressed in cells of premalignant high-grade prostatic intraepithelial neoplasia (HGPIN) and prostate adenocarcinoma. The majority of the carcinoma cells show a distinct granular cytoplasmic staining reaction. AMACR is present at low or undetectable levels in glandular epithelial cells of normal prostate and benign prostatic hyperplasia. A spotty granular cytoplasmic staining is seen in a few cells of the benign glands.