RAD50 Antikörper (AA 817-872)

Produktnummer ABIN4913428

Produktdetails anti-RAD50 Antikörper

Target: RAD50 (RAD50 Homolog (S. Cerevisiae) (RAD50))

Bindungsspezifität: AA 817-872

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RAD50 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS), Immunocytochemistry (ICC), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Kreuzreaktivität: Human, Maus

Homologie: Rat,Cow,Sheep,Horse,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human RAD50

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Details zu RAD50

Target: RAD50 (RAD50 Homolog (S. Cerevisiae) (RAD50))

Andere Bezeichnung: RAD50 (RAD50 Produkte)

Synonyme: NBSLD antikoerper, RAD502 antikoerper, hRad50 antikoerper, Mrell antikoerper, Rad50l antikoerper, 6339 antikoerper, CG6339 antikoerper, Dmel\\CG6339 antikoerper, Dmrad50 antikoerper, RAD50 antikoerper, Rad50 antikoerper, ATRAD50 antikoerper, DNA REPAIR-RECOMBINATION PROTEIN antikoerper, F22D22.28 antikoerper, F22D22_28 antikoerper, SPAP4C9.01c antikoerper, im:6906849 antikoerper, si:ch211-79h18.3 antikoerper, RAD50 double strand break repair protein antikoerper, CG6339 gene product from transcript CG6339-RE antikoerper, RAD50 homolog, double strand break repair protein L homeolog antikoerper, rad50 antikoerper, DNA repair protein RAD50 antikoerper, RAD50 homolog, double strand break repair protein antikoerper, DNA repair-recombination protein (RAD50) antikoerper, MRX complex DNA-binding subunit antikoerper, DNA repair protein Rad50 antikoerper, RAD50 recombination protein antikoerper, Rad50 DNA repair/recombination protein antikoerper, DNA repair protein rad-50 antikoerper, RAD50 antikoerper, Rad50 antikoerper, rad50 antikoerper, rad50.L antikoerper, LOC658288 antikoerper, LOC726642 antikoerper, rad-50 antikoerper

Hintergrund:

Synonyms: DNA repair protein RAD50, RAD50, hRAD50

Background: Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11A. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11A to prevent nucleolytic degradation past a given point (PubMed:11741547, PubMed:9590181, PubMed:9705271, PubMed:9651580). The complex may also be required for DNA damage signaling via activation of the ATM kinase (PubMed:15064416). In telomeres the MRN complex may modulate t-loop formation (PubMed:10888888).

Gen-ID: 10111

UniProt: Q92878

Pathways: DNA Reparatur, Protein targeting to Nucleus