RAD50 Antikörper (AA 1-100)

Produktnummer ABIN3017330

Produktdetails anti-RAD50 Antikörper

Target: RAD50 (RAD50 Homolog (S. Cerevisiae) (RAD50))

Bindungsspezifität: AA 1-100

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RAD50 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)

Sequenz: MSRIEKMSIL GVRSFGIEDK DKQIITFFSP LTILVGPNGA GKTTIIECLK YICTGDFPPG TKGNTFVHDP KVAQETDVRA QIRLQFRDVN GELIAVQRSM

Kreuzreaktivität: Human, Maus, Ratte

Produktmerkmale: Polyclonal Antibodies

Immunogen: A synthetic peptide corresponding to a sequence within amino acids 1-100 of human Rad50 (NP_005723.2).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000,IHC,1:50 - 1:200,IP,1:20 - 1:50

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Referenzen für anti-RAD50 Antikörper (ABIN3017330)

Zhang, Tang, Jiang, Mao: "The transcription factor GATA3 is required for homologous recombination repair by regulating CtIP expression." in: Oncogene, Vol. 36, Issue 36, pp. 5168-5176, (2017) (PubMed).

Details zu RAD50

Target: RAD50 (RAD50 Homolog (S. Cerevisiae) (RAD50))

Andere Bezeichnung: RAD50 (RAD50 Produkte)

Synonyme: NBSLD antikoerper, RAD502 antikoerper, hRad50 antikoerper, Mrell antikoerper, Rad50l antikoerper, 6339 antikoerper, CG6339 antikoerper, Dmel\\CG6339 antikoerper, Dmrad50 antikoerper, RAD50 antikoerper, Rad50 antikoerper, ATRAD50 antikoerper, DNA REPAIR-RECOMBINATION PROTEIN antikoerper, F22D22.28 antikoerper, F22D22_28 antikoerper, SPAP4C9.01c antikoerper, im:6906849 antikoerper, si:ch211-79h18.3 antikoerper, RAD50 double strand break repair protein antikoerper, CG6339 gene product from transcript CG6339-RE antikoerper, RAD50 homolog, double strand break repair protein L homeolog antikoerper, rad50 antikoerper, DNA repair protein RAD50 antikoerper, RAD50 homolog, double strand break repair protein antikoerper, DNA repair-recombination protein (RAD50) antikoerper, MRX complex DNA-binding subunit antikoerper, DNA repair protein Rad50 antikoerper, RAD50 recombination protein antikoerper, Rad50 DNA repair/recombination protein antikoerper, DNA repair protein rad-50 antikoerper, RAD50 antikoerper, Rad50 antikoerper, rad50 antikoerper, rad50.L antikoerper, LOC658288 antikoerper, LOC726642 antikoerper, rad-50 antikoerper

Hintergrund: The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Rad50, a protein involved in DNA double-strand break repair. This protein forms a complex with MRE11 and NBS1. The protein complex binds to DNA and displays numerous enzymatic activities that are required for nonhomologous joining of DNA ends. This protein, cooperating with its partners, is important for DNA double-strand break repair, cell cycle checkpoint activation, telomere maintenance, and meiotic recombination. Knockout studies of the mouse homolog suggest this gene is essential for cell growth and viability. Mutations in this gene are the cause of Nijmegen breakage syndrome-like disorder.,RAD50,NBSLD,RAD502,hRad50,Epigenetics & Nuclear Signaling,DNA Damage & Repair,Cell Biology & Developmental Biology,Cell Cycle,G2/M DNA Damage Checkpoint,RAD50

Molekulargewicht: 138 kDa/153 kDa/154 kDa

Gen-ID: 10111

UniProt: Q92878

Pathways: DNA Reparatur, Protein targeting to Nucleus