TGFB1 Antikörper

Produktnummer ABIN453911

Produktdetails anti-TGFB1 Antikörper

Target: TGFB1 (Transforming Growth Factor, beta 1 (TGFB1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser TGFB1 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Frozen Sections) (IHC (fro)), Enzyme Immunoassay (EIA), Functional Studies (Func)

Spezifität: Western blotting demonstrated that this TGF-beta antibody reacts to either dimeric (25 kDa) or monomeric (12.5 kDa) molecules of TGF-beta under non-reducing and reducing condition respectively. Recognizes both Human platelet-derived and recombinant TGF beta in ELISA.

Aufreinigung: Affinity Chromatography on Protein G.

Immunogen: TGF-beta from Human platelets.

Klon: 8C4

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: ELISA. Neutralizing Activity: This MAb neutralizes TGF beta activity in vitro in inhibition assay ofCCL/64 cell growth and also neutralize the growth promoting action of TGF-beta in theNRK-49F colony forming assays. The effect of micro-injection of this MAb into oneblastomere of two cell stage Xenopus embryos indicated that this MAb was able toneutralize effectively the bioactivity of TG beta in vivo. Immunohistochemistry: May be used in immunohistochemical techniques to locateTGF-beta within tissues.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Rekonstitution: Restore with Double distillated water to adjust the final concentration to 1.00 mg/mL.

Buffer: 0.01 M PBS, pH 7.0 without preservatives.

Konservierungsmittel: Without preservative

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C

Details zu TGFB1

Target: TGFB1 (Transforming Growth Factor, beta 1 (TGFB1))

Andere Bezeichnung: TGFB1 (TGFB1 Produkte)

Synonyme: CED antikoerper, DPD1 antikoerper, LAP antikoerper, TGFB antikoerper, TGFbeta antikoerper, TGF-beta antikoerper, TGF-BETA-1 antikoerper, TGF-beta5 antikoerper, ced antikoerper, dpd1 antikoerper, lap antikoerper, tgf-beta antikoerper, tgfb antikoerper, tgfb5 antikoerper, tgfbeta antikoerper, TGF-beta1 antikoerper, TGFbeta1 antikoerper, Tgfb antikoerper, Tgfb-1 antikoerper, ai39657 antikoerper, tgfb1 antikoerper, wu:fb13a07 antikoerper, xx:ai39657 antikoerper, TGFB1 antikoerper, csd antikoerper, cdb1 antikoerper, cdg2 antikoerper, csd1 antikoerper, csd2 antikoerper, csd3 antikoerper, ebmd antikoerper, lcd1 antikoerper, bigh3 antikoerper, cdgg1 antikoerper, betaig-h3 antikoerper, TGFB4 antikoerper, transforming growth factor beta 1 antikoerper, transforming growth factor beta-1 antikoerper, transforming growth factor beta 1 L homeolog antikoerper, transforming growth factor, beta 1 antikoerper, transforming growth factor, beta 1a antikoerper, transforming growth factor beta induced L homeolog antikoerper, TGFB1 antikoerper, Tgfb1 antikoerper, tgfb1.L antikoerper, tgfb1a antikoerper, tgfbi.L antikoerper

Hintergrund: TGF beta 1 (Transforming Growth Factor Beta 1) is a multifunctional peptide capable of influencing cell proliferation, differentiation, and other functions in a wide range of cell types. Transformed as well as non neoplastic tissues, release transforming growth factors, and essentially all cells possess a specific TGF beta 1 receptor. The multimodal nature of TGF beta 1 is seen in its ability to stimulate or inhibit cellular proliferation. TGF beta 1 plays a fundamental role in tissue growth and differentiation involvement in adipogenesis, myogenesis, chondrogenesis, osteogenesis, epithelial cell differentiation and immune cell function. The C-terminal 112 amino acids constitute the mature protein.Synonyms: TGF-beta-1, TGFB, Transforming growth factor beta-1

Gen-ID: 7040

NCBI Accession: NP_000651

UniProt: P01137

Pathways: EGFR Signaling Pathway, Dopaminergic Neurogenesis, Cellular Response to Molecule of Bacterial Origin, Glycosaminoglycan Metabolic Process, Regulation of Leukocyte Mediated Immunity, Regulation of Muscle Cell Differentiation, Positive Regulation of Immune Effector Process, Cell-Cell Junction Organization, Production of Molecular Mediator of Immune Response, Ribonucleoside Biosynthetic Process, Skeletal Muscle Fiber Development, Regulation of Carbohydrate Metabolic Process, Protein targeting to Nucleus, Autophagie, Cancer Immune Checkpoints