RIPK3 Antikörper (C-Term)

Produktnummer ABIN392275

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch RIPK3 in WB und IHC (p). Er zeigt eine Reaktivität gegenüber Human und Maus und wurde in 5+ Publikationen erwähnt.

Kurzübersicht für RIPK3 Antikörper (C-Term) (ABIN392275)

Target: RIPK3 (Receptor-Interacting serine-threonine Kinase 3 (RIPK3))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RIPK3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: RB3319

Produktdetails anti-RIPK3 Antikörper

Bindungsspezifität: AA 489-518, C-Term

Aufreinigung: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This RIPK3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 489-518 amino acids from the C-terminal region of human RIPK3.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000. WB: 1:1000. IHC-P: 1:50~100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid freeze-thaw cycles.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots.

Haltbarkeit: 6 months

Referenzen für anti-RIPK3 Antikörper (ABIN392275)

McCullough, McMullen, Das, Roychowdhury, Strainic, Medof, Nagy: "Differential contribution of complement receptor C5aR in myeloid and non-myeloid cells in chronic ethanol-induced liver injury in mice." in: Molecular immunology, Vol. 75, pp. 122-32, (2017) (PubMed).

Deutsch, Graffeo, Rokosh, Pansari, Ochi, Levie, Van Heerden, Tippens, Greco, Barilla, Tomkötter, Zambirinis, Avanzi, Gulati, Pachter, Torres-Hernandez, Eisenthal, Daley, Miller: "Divergent effects of RIP1 or RIP3 blockade in murine models of acute liver injury." in: Cell death & disease, Vol. 6, pp. e1759, (2015) (PubMed).

Dara, Johnson, Suda, Win, Gaarde, Han, Kaplowitz: "Receptor interacting protein kinase 1 mediates murine acetaminophen toxicity independent of the necrosome and not through necroptosis." in: Hepatology (Baltimore, Md.), (2015) (PubMed).

Roychowdhury, Chiang, Mandal, McMullen, Liu, Cohen, Pollard, Feldstein, Nagy: "Inhibition of apoptosis protects mice from ethanol-mediated acceleration of early markers of CCl4 -induced fibrosis but not steatosis or inflammation." in: Alcoholism, clinical and experimental research, Vol. 36, Issue 7, pp. 1139-47, (2012) (PubMed).

Zorde-Khvalevsky, Abramovitch, Barash, Spivak-Pohis, Rivkin, Rachmilewitz, Galun, Giladi: "Toll-like receptor 3 signaling attenuates liver regeneration." in: Hepatology (Baltimore, Md.), Vol. 50, Issue 1, pp. 198-206, (2009) (PubMed).

Details zu RIPK3

Target: RIPK3 (Receptor-Interacting serine-threonine Kinase 3 (RIPK3))

Andere Bezeichnung: RIPK3

Hintergrund: RIPK3 is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases, and contains a C-terminal domain unique from other RIP family members. The encoded protein is predominantly localized to the cytoplasm, and can undergo nucleocytoplasmic shuttling dependent on novel nuclear localization and export signals. It is a component of the tumor necrosis factor (TNF) receptor-I signaling complex, and can induce apoptosis and weakly activate the NF-kappaB transcription factor.

Molekulargewicht: 56887

Gen-ID: 11035

NCBI Accession: NP_006862

UniProt: Q9Y572

Pathways: Activation of Innate immune Response, Toll-Like Receptors Cascades