RIPK3 Antikörper (N-Term)

Produktnummer ABIN391272

Produktdetails anti-RIPK3 Antikörper

Target: RIPK3 (Receptor-Interacting serine-threonine Kinase 3 (RIPK3))

Bindungsspezifität: AA 1-30, N-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RIPK3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Aufreinigung: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This RIPK3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human RIPK3.

Klon: RB8631

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000. IHC-P: 1:10~50

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 6 months

Referenzen für anti-RIPK3 Antikörper (ABIN391272)

Viringipurampeer, Metcalfe, Bashar, Sivak, Yanai, Mohammadi, Moritz, Gregory-Evans, Gregory-Evans: "NLRP3 inflammasome activation drives bystander cone photoreceptor cell death in a P23H rhodopsin model of retinal degeneration." in: Human molecular genetics, Vol. 25, Issue 8, pp. 1501-16, (2016) (PubMed).

Viringipurampeer, Ferreira, DeMaria, Yoon, Shan, Moosajee, Gregory-Evans, Ngai, Gregory-Evans: "Pax2 regulates a fadd-dependent molecular switch that drives tissue fusion during eye development." in: Human molecular genetics, Vol. 21, Issue 10, pp. 2357-69, (2012) (PubMed).

Details zu RIPK3

Target: RIPK3 (Receptor-Interacting serine-threonine Kinase 3 (RIPK3))

Andere Bezeichnung: RIPK3 (RIPK3 Produkte)

Synonyme: RIPK3 antikoerper, RIP3 antikoerper, 2610528K09Rik antikoerper, AW107945 antikoerper, Rip3 antikoerper, Hcyp2 antikoerper, receptor interacting serine/threonine kinase 3 antikoerper, receptor interacting serine/threonine kinase 3 S homeolog antikoerper, receptor-interacting serine-threonine kinase 3 antikoerper, RIPK3 antikoerper, ripk3.S antikoerper, Ripk3 antikoerper

Hintergrund: The product of this gene is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases, and contains a C-terminal domain unique from other RIP family members. The encoded protein is predominantly localized to the cytoplasm, and can undergo nucleocytoplasmic shuttling dependent on novel nuclear localization and export signals. It is a component of the tumor necrosis factor (TNF) receptor-I signaling complex, and can induce apoptosis and weakly activate the NF-kappaB transcription factor.

Molekulargewicht: 56887

Gen-ID: 11035

NCBI Accession: NP_006862

UniProt: Q9Y572

Pathways: Activation of Innate immune Response, Toll-Like Receptors Cascades