RIPK3 Antikörper (AA 1-518)

Produktnummer ABIN7167480

Produktdetails anti-RIPK3 Antikörper

Target: RIPK3 (Receptor-Interacting serine-threonine Kinase 3 (RIPK3))

Bindungsspezifität: AA 1-518

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RIPK3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Receptor-interacting serine/threonine-protein kinase 3 protein (1-518AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200, IF:1:200-1:500,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu RIPK3

Target: RIPK3 (Receptor-Interacting serine-threonine Kinase 3 (RIPK3))

Andere Bezeichnung: RIPK3 (RIPK3 Produkte)

Synonyme: RIPK3 antikoerper, RIP3 antikoerper, 2610528K09Rik antikoerper, AW107945 antikoerper, Rip3 antikoerper, Hcyp2 antikoerper, receptor interacting serine/threonine kinase 3 antikoerper, receptor interacting serine/threonine kinase 3 S homeolog antikoerper, receptor-interacting serine-threonine kinase 3 antikoerper, RIPK3 antikoerper, ripk3.S antikoerper, Ripk3 antikoerper

Hintergrund:

Background: Essential for necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 and MLKL to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production.

Aliases: Receptor interacting protein 3 antibody, Receptor interacting serine threonine kinase 3 antibody, Receptor interacting serine/threonine protein kinase 3 antibody, Receptor-interacting protein 3 antibody, Receptor-interacting serine/threonine-protein kinase 3 antibody, RIP 3 antibody, RIP like protein kinase 3 antibody, RIP-3 antibody, RIP-like protein kinase 3 antibody, RIPK 3 antibody, RIPK3 antibody, RIPK3_HUMAN antibody

UniProt: Q9Y572

Pathways: Activation of Innate immune Response, Toll-Like Receptors Cascades