IRAK4 Antikörper (N-Term)

Produktnummer ABIN374511

Dieses Anti-IRAK4-Antikörper ist ein Ziege Polyklonal-Antikörper zur Detektion von IRAK4 in WB und EIA. Geeignet für Human und Maus.

Kurzübersicht für IRAK4 Antikörper (N-Term) (ABIN374511)

Target: IRAK4 (Interleukin-1 Receptor-Associated Kinase 4 (IRAK4))

Reaktivität: Human, Maus

Wirt: Ziege

Klonalität: Polyklonal

Konjugat: Dieser IRAK4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Produktdetails anti-IRAK4 Antikörper

Bindungsspezifität: N-Term

Sequenz: NKPITPSTYV RC

Spezifität: This antibody recognizes IRAK4 at N-term.

Kreuzreaktivität (Details): Species reactivity (expected):Mouse.
Species reactivity (tested):Human.

Aufreinigung: Affinity Chromatography

Immunogen: Peptide with sequence from the N Terminus of the protein sequence according to NP_057207.2, NP_001107654.1. Genename: IRAK4

Anwendungsinformationen

Applikationshinweise: Peptide ELISA: 1/32000. Western Blot: 1 - 3 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Tris saline containing 0.02 % Sodium Azide, pH 7.3 with 0.5 % BSA

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu IRAK4

Target: IRAK4 (Interleukin-1 Receptor-Associated Kinase 4 (IRAK4))

Andere Bezeichnung: IRAK4

Hintergrund: Interleukin 1 (IL1) and lipopolysaccharide (LPS) induces cellular responses through IL1 receptor (IL1R) and Toll like receptors (TLR). IL1R associated kinases (IRAK, IRAK2, and IRAKM) regulate the activation of NF-kB and MAP kinase (MAPK) by IL1R/TLR. A novel member in the IRAK/Pelle family was recently identified and designated IRAK4. Overexpression of IRAK4 activates NF-kB and MAPK pathways. IRAK4 interacts with and phosphorylates IRAK1. IRAK4 deficient animals are completely resistant to the challenge with LPS. Animals and humans lacking IRAK4 are impaired in their responses to viral and bacterial challenges. Members in IRAK/Pelle family play a central role in IL1R/TLR mediated inflammatory responses and in innate immunity.Synonyms: IRAK-4, Interleukin-1 receptor-associated kinase-like, NY-REN-64

Gen-ID: 51135

NCBI Accession: NP_001107654

UniProt: Q9NWZ3

Pathways: NF-kappaB Signalweg, TLR Signalweg, Activation of Innate immune Response, Toll-Like Receptors Cascades