HSD11B2 Antikörper (AA 25-40)

Produktnummer ABIN372479

Der Kaninchen Polyklonal Anti-HSD11B2-Antikörper wurde für WB und IHC (p) validiert. Er ist geeignet, HSD11B2 in Proben von Human, Maus und Ratte zu detektieren.

Kurzübersicht für HSD11B2 Antikörper (AA 25-40) (ABIN372479)

Target: HSD11B2 (Hydroxysteroid (11-Beta) Dehydrogenase 2 (HSD11B2))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HSD11B2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-HSD11B2 Antikörper

Bindungsspezifität: AA 25-40

Sequenz: R25SDLRLGRPLL AALAL4

Spezifität: This antibody recognizes 11-HSD2.

Kreuzreaktivität (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Aufreinigung: Immunoaffinity Chromatography.

Immunogen: Synthetic peptide corresponding to amino acids 25-40 of human 11 beta-HSD2.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot: 1/200. Immunohistochemistry on Paraffin Sections: 10 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: TBS, pH 7.4 containing 0.02 % Sodium Azide as preservative and 0.5 % BSA, 50 % Glycerol as stabilizers.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

Details zu HSD11B2

Target: HSD11B2 (Hydroxysteroid (11-Beta) Dehydrogenase 2 (HSD11B2))

Andere Bezeichnung: 11-beta HSD2 / HSD11B2

Hintergrund: HSD11B2 catalyzes the conversion of cortisol to the inactive metabolite cortisone. The protein modulates intracellular glucocorticoid levels, thus protecting the nonselective mineralocorticoid receptor from occupation by glucocorticoids. Defects in HSD11B2 are the cause of apparent mineralocorticoid excess (AME). AME is a potentially fatal disease characterized by severe juvenile low-renin hypertension, sodium retention, hypokalemia and low levels of aldosterone. It often leads to nephrocalcinosis.Synonyms: 11-DH2, 11-beta-hydroxysteroid dehydrogenase 2, Corticosteroid 11-beta-dehydrogenase isozyme 2, HSD11K, NAD-dependent 11-beta-hydroxysteroid dehydrogenase

Gen-ID: 3291

NCBI Accession: NP_000187

UniProt: P80365

Pathways: Steroid Hormone Biosynthesis, Regulation of Systemic Arterial Blood Pressure by Hormones