HSD11B2 Antikörper (AA 266-405)

Produktnummer ABIN6142000

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch HSD11B2 in WB. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für HSD11B2 Antikörper (AA 266-405) (ABIN6142000)

Target: HSD11B2 (Hydroxysteroid (11-Beta) Dehydrogenase 2 (HSD11B2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HSD11B2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-HSD11B2 Antikörper

Bindungsspezifität: AA 266-405

Sequenz: KTESVRNVGQ WEKRKQLLLA NLPQELLQAY GKDYIEHLHG QFLHSLRLAM SDLTPVVDAI TDALLAARPR RRYYPGQGLG LMYFIHYYLP EGLRRRFLQA FFISHCLPRA LQPGQPGTTP PQDAAQDPNL SPGPSPAVAR

Kreuzreaktivität: Human, Ratte

Produktmerkmale: Polyclonal Antibodies

Aufreinigung: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 266-405 of human HSD11B2 (NP_000187.3).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:200 - 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu HSD11B2

Target: HSD11B2 (Hydroxysteroid (11-Beta) Dehydrogenase 2 (HSD11B2))

Andere Bezeichnung: HSD11B2

Hintergrund: There are at least two isozymes of the corticosteroid 11-beta-dehydrogenase, a microsomal enzyme complex responsible for the interconversion of cortisol and cortisone. The type I isozyme has both 11-beta-dehydrogenase (cortisol to cortisone) and 11-oxoreductase (cortisone to cortisol) activities. The type II isozyme, encoded by this gene, has only 11-beta-dehydrogenase activity. In aldosterone-selective epithelial tissues such as the kidney, the type II isozyme catalyzes the glucocorticoid cortisol to the inactive metabolite cortisone, thus preventing illicit activation of the mineralocorticoid receptor. In tissues that do not express the mineralocorticoid receptor, such as the placenta and testis, it protects cells from the growth-inhibiting and/or pro-apoptotic effects of cortisol, particularly during embryonic development. Mutations in this gene cause the syndrome of apparent mineralocorticoid excess and hypertension.,HSD11B2,AME,AME1,HSD11K,HSD2,SDR9C3,Cancer,Signal Transduction,Cell Biology & Developmental Biology,Growth factor,Endocrine & Metabolism,Cardiovascular,Hypoxia,Heart,Cardiovascular diseases,Hypertension,Heart disease,HSD11B2

Molekulargewicht: 44 kDa

Gen-ID: 3291

UniProt: P80365

Pathways: Steroid Hormone Biosynthesis, Regulation of Systemic Arterial Blood Pressure by Hormones