CD36 Antikörper (Extracellular Domain)

Produktnummer ABIN350201

Der Kaninchen Polyklonal Anti-CD36-Antikörper wurde für WB und IHC validiert. Er ist geeignet, CD36 in Proben von Human zu detektieren.

Kurzübersicht für CD36 Antikörper (Extracellular Domain) (ABIN350201)

Target: CD36

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CD36 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-CD36 Antikörper

Bindungsspezifität: Extracellular Domain

Verwendungszweck: Rabbit antibody to CD36

Spezifität: Specific for CD36.

Kreuzreaktivität: Human

Kreuzreaktivität (Details): Other species not yet tested.

Aufreinigung: IgG

Immunogen: A synthetic peptide from extracellular domain of human CD36 (Fatty acid translocase) conjugated to blue carrier protein was used as the antigen.

Anwendungsinformationen

Applikationshinweise: IHC WB. A concentration of 10-50 μg,ml is recommended. The optimal concentration should be determined by the end user. Not yet tested in other applications.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material.

Handhabung: Avoid freeze and thaw cycles.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain the lyophilised/reconstituted antibodies frozen at -20C for long term storage and refrigerated at 2-8C for a shorter term. When reconstituting glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Haltbarkeit: 12 months

Details zu CD36

Target: CD36

Andere Bezeichnung: CD36

Hintergrund: FUNCTION: Seems to have numerous potential physiological functions. Recent compelling evidence from rodent and human studies raise the possibility for an additional sixth taste modality devoted to the perception of lipids. Recent studies strongly suggest that lingual CD36 being implicated in the perception of dietary fat may act as a gustatory lipid sensor (1). Binds to collagen thrombospondin anionic phospholipids and oxidized LDL. May function as a cell adhesion molecule. Directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes. Binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Defects in CD36 are the cause of platelet glycoprotein IV deficiency, also known as CD36 deficiency. Platelet glycoprotein IV deficiency can be divided into 2 subgroups. The type I phenotype is characterized by platelets and monocytes/macrophages exhibiting complete CD36 deficiency. The type II phenotype lacks the surface expression of CD36 in platelets but expression in monocytes/macrophages is near normal. SUBCELLULAR LOCATION: Cell membrane, Multi-pass membrane protein.

UniProt: P16671

Pathways: TLR Signalweg, Peptide Hormone Metabolism, Response to Growth Hormone Stimulus, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Regulation of Lipid Metabolism by PPARalpha, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Hepatitis C, Toll-Like Receptors Cascades, Lipid Metabolism, S100 Proteine