CD14 Antikörper (AA 33-44)
Kurzübersicht für CD14 Antikörper (AA 33-44) (ABIN343171)
Target
Alle CD14 Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
Klon
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Bindungsspezifität
- AA 33-44
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Spezifität
- Soluble and membrane bound human CD14. The antibody don't block LPS binding to membrane bound CD14.
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Aufreinigung
- Protein A affinity column
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Immunogen
- human Monocytes
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Isotyp
- IgG2a
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Applikationshinweise
- no significant inhibition of LPS binding to CD14
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Lyophilized
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Rekonstitution
- Reconstitute with bidistilled water
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Konzentration
- 1 mg/mL
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Buffer
- PBS, pH 7.8
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Konservierungsmittel
- Without preservative
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Lagerung
- -20 °C,-80 °C
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- CD14
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Andere Bezeichnung
- CD14
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Hintergrund
- Background: biG 4 represents an excellent marker for CD14. The CD14 glycoprotein, gp 55, is present on most monocytic and macrophages like cell types: monocytes, macrophages, weekly at surface of neutrophiles like Kupffer cells, pleural phagocytic cells and dendritic reticular cells. CD14 is also observed on granulocytes and activated or transformed B-cells. Furthermore CD14 is present in a soluble form in human serum, urine and other body fluids. The CD14 Molecule has been reported to be a receptor for endotoxin. CD14 is anchored to cells by linkage to glycosylphosphatidylinositol (GPI) and functions as a high affinity receptor for LPS-LBP (lipopolysaccharide binding protein)-complexes.
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Molekulargewicht
- ~50kDa
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Gen-ID
- 929
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NCBI Accession
- NP_000582
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UniProt
- P08571
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Pathways
- TLR Signalweg, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Toll-Like Receptors Cascades
Target
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