CD14
Reaktivität: Human
WB, IHC
Wirt: Maus
Monoclonal
LPSR-2397
unconjugated
Applikationshinweise
Flow Cytometry: Use 10 μL of neat antibody to label 1x10^6 cells in 100 μL. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung
4 °C
Informationen zur Lagerung
Prior to and following reconstitution store the antibody at 2-8 °C. DO NOT FREEZE! Shelf life: one year from despatch.
Haltbarkeit
12 months
Target
CD14
Andere Bezeichnung
CD14
Hintergrund
CD14 is a 55kD a glycophosphoinositol-linked cell surface protein that also exists in a soluble form. Expression of CD14 is restricted to the myeloid lineage and is predominantly expressed on peripheral blood monocytes, weakly expressed on granulocytes and absent on myeloid progenitors. The CD14 Molecule acts as a pattern recognition receptor, which binds lipopolysaccharide (LPS) and other microbial products such as lipoteichoic acid, lipoproteins and peptidoglycan. Binding of LPS to CD14 mediates the innate immune response to LPS and requires the Toll-like receptor-4 (TLR4)/MD-2 complex for effective signalling.Synonyms: Monocyte differentiation antigen CD14, Myeloid cell-specific leucine-rich glycoprotein