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FGF19 Antikörper (Middle Region)

FGF19 Reaktivität: Human WB, IHC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN3044409
  • Target Alle FGF19 Antikörper anzeigen
    FGF19 (Fibroblast Growth Factor 19 (FGF19))
    Bindungsspezifität
    • 8
    • 5
    • 5
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 124-140, Middle Region
    Reaktivität
    • 34
    • 3
    • 2
    • 2
    Human
    Wirt
    • 26
    • 6
    • 2
    • 1
    Kaninchen
    Klonalität
    • 25
    • 8
    • 1
    Polyklonal
    Konjugat
    • 24
    • 4
    • 2
    • 2
    • 1
    • 1
    Dieser FGF19 Antikörper ist unkonjugiert
    Applikation
    • 28
    • 21
    • 9
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Verwendungszweck
    Anti-Fibroblast growth factor 19 FGF19 Antibody Picoband®
    Sequenz
    EEIRPDGYNV YRSEKHR
    Kreuzreaktivität (Details)
    No cross-reactivity with other proteins
    Produktmerkmale
    Anti-Fibroblast growth factor 19 FGF19 Antibody (ABIN3044409). Tested in IHC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
    Aufreinigung
    Immunogen affinity purified.
    Immunogen
    A synthetic peptide corresponding to a sequence in the middle region of human FGF19.
    Isotyp
    IgG
    Top Product
    Discover our top product FGF19 Primärantikörper
  • Applikationshinweise
    Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human
    Western blot, 0.1-0.5 μg/mL, Human
    1. Kir, S., Beddow, S. A., Samuel, V. T., Miller, P., Previs, S. F., Suino-Powell, K., Xu, H. E., Shulman, G. I., Kliewer, S. A. , Mangelsdorf, D. J.FGF19 as a postprandial, insulin-independent activator of hepatic protein and glycogen synthesis. 2. Ladher, R. K., Anakwe, K. U., Gurney, A. L., Schoenwolf, G. C., Francis-West, P. H.Identification of synergistic signals initiating inner ear development. 3. Nishimura, T., Utsunomiya, Y., Hoshikawa, M., Ohuchi, H., Itoh, N.Structure and expression of a novel human FGF, FGF-19, expressed in the fetal brain. Biochim. Biophys. Acta 1444: 148-151, 1999.
    Kommentare

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    Konzentration
    500 μg/mL
    Buffer
    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.
    Konservierungsmittel
    Thimerosal (Merthiolate), Sodium azide
    Vorsichtsmaßnahmen
    This product contains Thimerosal (Merthiolate) and Sodium azide: POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
    Haltbarkeit
    12 months
  • Target
    FGF19 (Fibroblast Growth Factor 19 (FGF19))
    Andere Bezeichnung
    FGF19 (FGF19 Produkte)
    Hintergrund

    Synonyms: Fibroblast growth factor 19,FGF-19,FGF19,UNQ334/PRO533,

    Tissue Specificity: Expressed in fetal brain, cartilage, retina, and adult gall bladder. .

    Background: FGF19, Fibroblast growth factor 19, is a protein that in humans is encoded by the FGF19 gene. The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. The FGF19 gene is mapped to 11q13.3. The deduced 216-amino acid FGF19 protein contains asignal sequence and 2 cysteine residues that are conserved in the FGF family. Expression of this gene was detected only in fetal but not adult brain tissue. Synergistic interaction of the chick homolog and Wnt-8c has been shown to be required for initiation of inner ear development. FGF19 stimulates hepatic protein and glycogen synthesis but does not induce lipogenesis. The effects of FGF19 are independent of the activity of either insulin or the protein kinase Akt and, instead, are mediated through a mitogen-activated protein kinase signaling pathway that activates components of the protein translation machinery and stimulates glycogen synthase activity.

    Molekulargewicht
    24 kDa
    UniProt
    O95750
    Pathways
    RTK Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung
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