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MAP2K3 Antikörper (C-Term)

Der Kaninchen Polyklonal Anti-MAP2K3-Antikörper wurde für WB, IHC, IF, ICC und FACS validiert. Er ist geeignet, MAP2K3 in Proben von Human, Maus und Ratte zu detektieren. Es sind 2+ Publikationen verfügbar.
Produktnummer ABIN3043874

Kurzübersicht für MAP2K3 Antikörper (C-Term) (ABIN3043874)

Target

Alle MAP2K3 Antikörper anzeigen
MAP2K3 (Mitogen-Activated Protein Kinase Kinase 3 (MAP2K3))

Reaktivität

  • 131
  • 100
  • 78
  • 11
  • 10
  • 6
  • 5
  • 5
  • 4
  • 3
  • 1
  • 1
  • 1
  • 1
Human, Maus, Ratte

Wirt

  • 136
  • 11
Kaninchen

Klonalität

  • 126
  • 21
Polyklonal

Konjugat

  • 71
  • 8
  • 6
  • 5
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 2
  • 2
  • 1
  • 1
Dieser MAP2K3 Antikörper ist unkonjugiert

Applikation

  • 117
  • 46
  • 40
  • 39
  • 38
  • 24
  • 22
  • 11
  • 9
  • 9
  • 4
  • 2
  • 1
  • 1
  • 1
Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC), Flow Cytometry (FACS)
  • Bindungsspezifität

    • 26
    • 15
    • 15
    • 11
    • 10
    • 8
    • 7
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 311-347, C-Term

    Verwendungszweck

    Anti-MEK3/MAP2K3 Antibody Picoband®

    Sequenz

    AERMSYLELM EHPFFTLHKT KKTDIAAFVK EILGEDS

    Kreuzreaktivität (Details)

    No cross-reactivity with other proteins.

    Produktmerkmale

    Anti-MEK3/MAP2K3 Antibody Picoband® (ABIN3043874). Tested in Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

    Aufreinigung

    Immunogen affinity purified.

    Immunogen

    A synthetic peptide corresponding to a sequence at the C-terminus of human MEK3, identical to the related mouse sequence.

    Isotyp

    IgG
  • Applikationshinweise

    Western blot, 0.25-0.5 μg/mL, Human, Mouse, Rat
    Immunohistochemistry (Paraffin-embedded Section), 2-5 μg/mL, Human
    Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human
    Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human
    1. Rampoldi L, Zimbello R, Bortoluzzi S, Tiso N, Valle G, Lanfranchi G, Danieli GA (Mar 1998). "Chromosomal localization of four MAPK signaling cascade genes: MEK1, MEK3, MEK4 and MEKK5". Cytogenet Cell Genet 78 (3-4): 301-3.

    Kommentare

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Lyophilized

    Rekonstitution

    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

    Konzentration

    500 μg/mL

    Buffer

    Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

    Handhabung

    Avoid repeated freezing and thawing.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
  • Cheng, Wang, Wang, Wang, Du, Lou: "Silencing Ras-Related C3 Botulinum Toxin Substrate 1 Inhibits Growth and Migration of Hypopharyngeal Squamous Cell Carcinoma via the P38 Mitogen-Activated Protein Kinase Signaling Pathway." in: Medical science monitor : international medical journal of experimental and clinical research, Vol. 24, pp. 768-781, (2018) (PubMed).

    Xu, Zhang, Wei, Jia, Ge, Zhang, Liu: "MicroRNA-21 promotes hepatocellular carcinoma HepG2 cell proliferation through repression of mitogen-activated protein kinase-kinase 3." in: BMC cancer, Vol. 13, pp. 469, (2013) (PubMed).

  • Target

    MAP2K3 (Mitogen-Activated Protein Kinase Kinase 3 (MAP2K3))

    Andere Bezeichnung

    MAP2K3

    Hintergrund

    Synonyms: Dual specificity mitogen-activated protein kinase kinase 3,MAP kinase kinase 3,MAPKK 3,2.7.12.2,MAPK/ERK kinase 3,MEK 3,Stress-activated protein kinase kinase 2,SAPK kinase 2,SAPKK-2,SAPKK2,MAP2K3,MEK3, MKK3, PRKMK3, SKK2,

    Tissue Specificity: Abundant expression is seen in the skeletal muscle. It is also widely expressed in other tissues.

    Background: Dual specificity mitogen-activated protein kinase kinase 3 is an enzyme that in humans is encoded by the MAP2K3 gene. The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. And this kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. Rampoldi et al. (1997) localized the MAP2K3 gene to 17q11.2.

    Molekulargewicht

    40 kDa

    Gen-ID

    5606

    UniProt

    P46734

    Pathways

    MAPK Signalweg, TLR Signalweg, Activation of Innate immune Response, Toll-Like Receptors Cascades, Autophagie, Signaling Events mediated by VEGFR1 and VEGFR2
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