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Caspase 6 Antikörper (N-Term)

Dieses Anti-Caspase 6-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von Caspase 6 in WB, IHC und FACS. Geeignet für Human.
Produktnummer ABIN3043219

Kurzübersicht für Caspase 6 Antikörper (N-Term) (ABIN3043219)

Target

Alle Caspase 6 (CASP6) Antikörper anzeigen
Caspase 6 (CASP6) (Caspase 6, Apoptosis-Related Cysteine Peptidase (CASP6))

Reaktivität

  • 146
  • 81
  • 39
  • 19
  • 3
  • 2
  • 1
  • 1
Human

Wirt

  • 160
  • 26
  • 1
Kaninchen

Klonalität

  • 149
  • 38
Polyklonal

Konjugat

  • 99
  • 16
  • 12
  • 7
  • 5
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
Dieser Caspase 6 Antikörper ist unkonjugiert

Applikation

  • 153
  • 82
  • 62
  • 41
  • 40
  • 37
  • 30
  • 29
  • 22
  • 18
  • 12
  • 5
  • 4
  • 3
  • 1
Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS)
  • Bindungsspezifität

    • 26
    • 21
    • 16
    • 15
    • 8
    • 8
    • 8
    • 7
    • 6
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 24-44, N-Term

    Verwendungszweck

    Anti-Caspase-6(P18)/CASP6 Antibody Picoband®

    Sequenz

    AFYKREMFDP AEKYKMDHRR R

    Kreuzreaktivität (Details)

    No cross-reactivity with other proteins

    Produktmerkmale

    Anti-Caspase-6 (P18)/CASP6 Antibody (ABIN3043219). Tested in Flow Cytometry, IHC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

    Aufreinigung

    Immunogen affinity purified.

    Immunogen

    A synthetic peptide corresponding to a sequence at the N-terminus of human Caspase-6(P18).

    Isotyp

    IgG
  • Applikationshinweise

    Western blot, 0.1-0.5 μg/mL, Human
    Immunohistochemistry (Paraffin-embedded Section), 2-5 μg/mL, Human
    Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human
    1. Fernandes-Alnemri, T., Litwack, G., Alnemri, E. S.Mch2, a new member of the apoptotic Ced-3/Ice cysteine protease gene family.Cancer Res. 55: 2737-2742, 1995. 2. Nikolaev, A., McLaughlin, T., O'Leary, D. D. M., Tessier-Lavigne, M.APP binds DR6 to trigger axon pruning and neuron death via distinct caspases Nature 457: 981-989, 2009. 3. Orth, K., Chinnaiyan, A. M., Garg, M., Froelich, C. J., Dixit, V. M.The CED-3/ICE-like protease Mch2 is activated during apoptosis and cleaves the death substrate lamin A.J. Biol. Chem. 271: 16443-16446, 1996.

    Kommentare

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Lyophilized

    Rekonstitution

    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

    Konzentration

    500 μg/mL

    Buffer

    Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

    Handhabung

    Avoid repeated freezing and thawing.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

    Haltbarkeit

    12 months
  • Target

    Caspase 6 (CASP6) (Caspase 6, Apoptosis-Related Cysteine Peptidase (CASP6))

    Andere Bezeichnung

    CASP6

    Hintergrund

    Synonyms: Caspase-6,CASP-6,3.4.22.59,Apoptotic protease Mch-2,Caspase-6 subunit p18,Caspase-6 subunit p11,CASP6,MCH2,

    Tissue Specificity: High level expression seen in spleen and lung, low level expression seen in brain, heart, liver, kidney, testis and skeletal muscle.

    Background: Caspase 6 is an enzyme that in humans is encoded by the caspase 6 gene. This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Using radiation hybrid mapping, the Caspase 6 gene is localized to human chromosome 4q25-q26. Caspase 6 functions as a downstream enzyme in the caspase activation cascade. And Caspase 6 can cleave lamin A to its signature apoptotic fragment.

    Sequence Similarities: Belongs to the peptidase C14A family.

    Molekulargewicht

    35 kDa

    UniProt

    P55212

    Pathways

    Apoptose, Caspase Kaskade in der Apoptose
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