MAP2K3 Antikörper (N-Term)

Produktnummer ABIN3031842

Dieses Anti-MAP2K3-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von MAP2K3 in WB. Geeignet für Human, Maus und Ratte.

Kurzübersicht für MAP2K3 Antikörper (N-Term) (ABIN3031842)

Target: MAP2K3 (Mitogen-Activated Protein Kinase Kinase 3 (MAP2K3))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MAP2K3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-MAP2K3 Antikörper

Bindungsspezifität: N-Term

Aufreinigung: Antigen affinity

Immunogen: An amino acid sequence from the N-terminus of human MEK3 (RNLDSRTFITIGDRNFE) was used as the immunogen for this MEK3 antibody (100% homologous in human, mouse and rat).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: The stated application concentrations are suggested starting amounts. Titration of the MEK3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: -20 °C

Informationen zur Lagerung: After reconstitution, the MEK3 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Details zu MAP2K3

Target: MAP2K3 (Mitogen-Activated Protein Kinase Kinase 3 (MAP2K3))

Andere Bezeichnung: MEK3

Hintergrund: Dual specificity mitogen-activated protein kinase kinase 3 is an enzyme that in humans is encoded by the MAP2K3 gene. The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. Rampoldi et al.(1997) localized the MAP2K3 gene to 17q11.2.

UniProt: P46734

Pathways: MAPK Signalweg, TLR Signalweg, Activation of Innate immune Response, Toll-Like Receptors Cascades, Autophagie, Signaling Events mediated by VEGFR1 and VEGFR2