CD11b Antikörper

Produktnummer ABIN3024274

Der Ratte Monoklonal anti-CD11b Antikörper (Klon M1-70) (ABIN3024274) detektiert spezifisch CD11b in FACS, IF und Func. Dieser Antikörper reagiert spezifisch mit Proben aus Human und Maus.

Kurzübersicht für CD11b Antikörper (ABIN3024274)

Target: CD11b (ITGAM) (Integrin alpha M (ITGAM))

Reaktivität: Human, Maus

Wirt: Ratte

Klonalität: Monoklonal

Konjugat: Dieser CD11b Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), Immunofluorescence (IF), Functional Studies (Func)

Güteklasse: Carrier-free

Klon: M1-70

Produktdetails anti-CD11b Antikörper

Verwendungszweck: CD11b Antibody / MAC-1 / ITGAM (azide and preservative free)

Aufreinigung: Protein G affinity chromatography

Immunogen: B10 mouse spleen cells enriched for T lymphocytes were used as the immunogen for this CD11b antibody.

Isotyp: IgG2b, kappa

Anwendungsinformationen

Applikationshinweise: The concentration stated for each application is a general starting point. Variations in protocols, secondaries and substrates may require the CD11b antibody to be titered up or down for optimal performance.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Konservierungsmittel: Azide free

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store the CD11b antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Details zu CD11b

Target: CD11b (ITGAM) (Integrin alpha M (ITGAM))

Andere Bezeichnung: CD11b

Hintergrund: CD11b is a cell adhesion molecule that acts as a receptor for cell surface ligands such as intracellular adhesion molecules (ICAMs) or soluble ligands. Integrins are heterodimeric proteins that contain an a chain and b chain. Integrin alpha-M (CD11b) combines with the Integrin beta-2 (CD18) to form a leukocyte-specific integrin referred to as macrophage receptor 1 (Mac-1), or inactivated-C3b (iC3b) receptor 3 (CR3). Integrin alpha-M/beta-2 is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles.

Pathways: Apoptose, Activation of Innate immune Response, Toll-Like Receptors Cascades, Activated T Cell Proliferation