CD11b Antikörper (AA 145-340)

Produktnummer ABIN3022180

Dieses Anti-CD11b-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von CD11b in IHC, WB und IF. Geeignet für Human. Dieses Primary Antibody wurde in 1 Publikation zitiert.

Kurzübersicht für CD11b Antikörper (AA 145-340) (ABIN3022180)

Target: CD11b (ITGAM) (Integrin alpha M (ITGAM))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CD11b Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), Western Blotting (WB), Immunofluorescence (IF)

Produktdetails anti-CD11b Antikörper

Bindungsspezifität: AA 145-340

Sequenz: PQEDSDIAFL IDGSGSIIPH DFRRMKEFVS TVMEQLKKSK TLFSLMQYSE EFRIHFTFKE FQNNPNPRSL VKPITQLLGR THTATGIRKV VRELFNITNG ARKNAFKILV VITDGEKFGD PLGYEDVIPE ADREGVIRYV IGVGDAFRSE KSRQELNTIA SKPPRDHVFQ VNNFEALKTI QNQLREKIFA IEGTQT

Kreuzreaktivität: Human, Maus, Ratte

Produktmerkmale: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 145-340 of CD11b/ITGAM (NP_000623.2).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid freeze / thaw cycles

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Referenzen für anti-CD11b Antikörper (ABIN3022180)

Wang, Zheng, Gu, Cai, Wang, Zhang, Chen, Situ, Lin, Wang: "Network-pharmacology-based validation of TAMS/CXCL-1 as key mediator of XIAOPI formula preventing breast cancer development and metastasis." in: Scientific reports, Vol. 7, Issue 1, pp. 14513, (2017) (PubMed).

Details zu CD11b

Target: CD11b (ITGAM) (Integrin alpha M (ITGAM))

Andere Bezeichnung: ITGAM

Hintergrund: This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding different isoforms have been found for this gene.,CD11B,CR3A,MAC-1,MAC1A,MO1A,SLEB6,ITGAM,CD11b/ITAM,Signal Transduction,G protein signaling,G2/M DNA Damage Checkpoint,PI3K-Akt Signaling Pathway,MAPK-Erk Signaling Pathway,Cell Biology & Developmental Biology,Cell Adhesion,Cytoskeleton,Immunology & Inflammation,CD markers,Neuroscience,Cell Type Marker,Stem Cells,Hematopoietic Progenitors,Mesenchymal Stem Cells,Microglia marker,ITGAM

Molekulargewicht: 127 kDa

Gen-ID: 3684

UniProt: P11215

Pathways: Apoptose, Activation of Innate immune Response, Toll-Like Receptors Cascades, Activated T Cell Proliferation