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PRKACA Antikörper (Center)

Dieses Anti-PRKACA-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von PRKACA in WB, IHC (p), IF und ICC. Geeignet für Human und Maus.
Produktnummer ABIN2855997

Kurzübersicht für PRKACA Antikörper (Center) (ABIN2855997)

Target

Alle PRKACA Antikörper anzeigen
PRKACA (Protein Kinase A, alpha (PRKACA))

Reaktivität

  • 51
  • 36
  • 14
  • 4
  • 4
  • 4
  • 3
  • 3
  • 2
  • 2
  • 2
Human, Maus

Wirt

  • 55
  • 10
  • 2
  • 1
Kaninchen

Klonalität

  • 57
  • 11
Polyklonal

Konjugat

  • 42
  • 4
  • 3
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser PRKACA Antikörper ist unkonjugiert

Applikation

  • 52
  • 28
  • 15
  • 13
  • 13
  • 10
  • 8
  • 5
  • 3
  • 2
  • 2
  • 2
  • 1
  • 1
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF), Immunocytochemistry (ICC)
  • Bindungsspezifität

    • 15
    • 7
    • 5
    • 5
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Center

    Kreuzreaktivität

    Ratte (Rattus), Hund, Schaf, Rind (Kuh)

    Kreuzreaktivität (Details)

    Rat (100 %), Dog (100 %), Sheep (100 %), Bovine (100 %)

    Produktmerkmale

    Rabbit Polyclonal antibody to PKA C alpha (protein kinase, cAMP-dependent, catalytic, alpha)
    PKA C alpha antibody [N2C3]

    Aufreinigung

    Purified by antigen-affinity chromatography.

    Immunogen

    Recombinant protein encompassing a sequence within the center region of human PKA C alpha. The exact sequence is proprietary.

    Isotyp

    IgG
  • Applikationshinweise

    Suggested dilution Reference ICC/IF 1:100-1:1000* IHC (Formalin-fixed paraffin-embedded sections) 1:100-1:1000* Western blot 1:500-1:3000* Not tested in other applications. *Optimal dilutions/concentrations should be determined by the researcher.Suggested dilutionReferenceICC/IF1:100-1:1000* IHC (Formalin-fixed paraffin-embedded sections)1:100-1:1000* Western blot1:500-1:3000*

    Kommentare

    Positive Control: HeLa , Jurkat , NT2D1 , mouse brain

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    0.38 mg/mL

    Buffer

    0.1M Tris, 0.1M Glycine, 10 % Glycerol ( pH 7). 0.01 % Thimerosal was added as a preservative.

    Konservierungsmittel

    Thimerosal (Merthiolate)

    Vorsichtsmaßnahmen

    This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
  • Target

    PRKACA (Protein Kinase A, alpha (PRKACA))

    Andere Bezeichnung

    PKA C alpha

    Hintergrund

    CAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is a member of the Ser/Thr protein kinase family and is a catalytic subunit of cAMP-dependent protein kinase. Alternatively spliced transcript variants encoding distinct isoforms have been observed.

    Cellular Localization: Cytoplasm (By similarity) , Nucleus (By similarity)

    Molekulargewicht

    41 kDa

    Gen-ID

    5566

    Pathways

    NF-kappaB Signalweg, Hedgehog Signalweg, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Thyroid Hormone Synthesis, Carbohydrate Homeostasis, Myometrial Relaxation and Contraction, M Phase, G-protein mediated Events, Signaling Events mediated by VEGFR1 and VEGFR2, Interaction of EGFR with phospholipase C-gamma, Thromboxane A2 Receptor Signaling, VEGFR1 Specific Signals, Lipid Metabolism, SARS-CoV-2 Protein Interaktom, Phosphorylierungen bei SARS-CoV-2 Infektion
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