Growth Hormone Receptor Antikörper

Produktnummer ABIN2854312

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch Growth Hormone Receptor in IHC (p). Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für Growth Hormone Receptor Antikörper (ABIN2854312)

Target: Growth Hormone Receptor (GHR)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Growth Hormone Receptor Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-Growth Hormone Receptor Antikörper

Kreuzreaktivität: Human

Produktmerkmale: Rabbit Polyclonal antibody to Growth hormone Receptor (growth hormone receptor)
Growth hormone Receptor antibody [N3C2], Internal

Aufreinigung: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein encompassing a sequence within the center region of human Growth hormone Receptor. The exact sequence is proprietary.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.7 mg/mL

Buffer: 0.1M Tris-Glycine ( pH 7), 10 % Glycerol, 0.01 % Thimerosal

Konservierungsmittel: Thimerosal (Merthiolate)

Vorsichtsmaßnahmen: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Details zu Growth Hormone Receptor

Target: Growth Hormone Receptor (GHR)

Andere Bezeichnung: growth hormone receptor

Hintergrund: This gene encodes a protein that is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. A common alternate allele of this gene, called GHRd3, lacks exon three and has been well-characterized. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature. Other splice variants, including one encoding a soluble form of the protein (GHRtr), have been observed but have not been thoroughly characterized. In humans and rabbits, but not rodents, growth hormone binding protein (GHBP) is generated by proteolytic cleavage of the extracellular ligand-binding domain from the mature growth hormone receptor protein. The precise location of this cleavage site has not been determined for the human protein.

Cellular Localization: Cell membrane, Single-pass type I membrane protein , Isoform 2: Cell membrane, Single-pass type I membrane protein , Growth hormone-binding protein: Secreted

Molekulargewicht: 72 kDa

Gen-ID: 2690

UniProt: P10912

Pathways: NF-kappaB Signalweg, JAK-STAT Signalweg, Response to Growth Hormone Stimulus