Telefon:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@antikoerper-online.de

VAV1 Antikörper (Middle Region)

VAV1 Reaktivität: Human, Ratte, Maus, Hund, Pferd, Rind (Kuh), Schwein, Kaninchen WB Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN2792554
  • Target Alle VAV1 Antikörper anzeigen
    VAV1 (Vav 1 Oncogene (VAV1))
    Bindungsspezifität
    • 15
    • 11
    • 10
    • 7
    • 7
    • 6
    • 6
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Middle Region
    Reaktivität
    Human, Ratte, Maus, Hund, Pferd, Rind (Kuh), Schwein, Kaninchen
    Wirt
    • 67
    • 4
    Kaninchen
    Klonalität
    • 67
    • 4
    Polyklonal
    Konjugat
    • 40
    • 5
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    Dieser VAV1 Antikörper ist unkonjugiert
    Applikation
    • 46
    • 34
    • 12
    • 7
    • 6
    • 5
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Sequenz
    RDRSELSLKE GDIIKILNKK GQQGWWRGEI YGRVGWFPAN YVEEDYSEYC
    Kreuzreaktivität
    Rind (Kuh), Hund, Human, Maus, Ratte (Rattus)
    Homologie
    Cow: 92%, Dog: 92%, Horse: 92%, Human: 100%, Mouse: 92%, Pig: 92%, Rabbit: 90%, Rat: 92%
    Produktmerkmale
    This is a rabbit polyclonal antibody against VAV1. It was validated on Western Blot using a cell lysate as a positive control.
    Aufreinigung
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the middle region of human VAV1
    Top Product
    Discover our top product VAV1 Primärantikörper
  • Applikationshinweise
    WB Suggested Anti-VAV1 Antibody Titration: 0.2-1 µg/mL
    ELISA Titer: 1:62500
    Positive Control: Human heart.
    Optimal working dilutions should be determined experimentally by the investigator.
    Kommentare

    Antigen size: 845 AA

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freeze-thaw cycles.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target
    VAV1 (Vav 1 Oncogene (VAV1))
    Andere Bezeichnung
    VAV1 (VAV1 Produkte)
    Synonyme
    VAV antikoerper, Vav antikoerper, vav-T antikoerper, vav guanine nucleotide exchange factor 1 antikoerper, vav 1 oncogene antikoerper, vav guanine nucleotide exchange factor 1 L homeolog antikoerper, VAV1 antikoerper, Vav1 antikoerper, vav1.L antikoerper
    Hintergrund
    This protein is a member of the Dbl family of guanine nucleotide exchange factors (GEF) for the Rho family of GTP binding proteins. The protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. This particular GEF has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication.The protein encoded by this proto-oncogene is a member of the Dbl family of guanine nucleotide exchange factors (GEF) for the Rho family of GTP binding proteins. The protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. This particular GEF has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
    Alias Symbols: VAV
    Protein Interaction Partner: UBC, CD28, ERBB3, ERBB2, EGFR, PTPN22, SPI1, PLCG1, Mbp, CD5, PDGFRB, NOTCH1, FGFR1, DOK1, TUBB, SH3BP2, CBLB, CBL, FYN, SYK, LCP2, CD19, SOCS1, KHDRBS1, LMNA, TUBA1A, PHAX, ZAP70, ZNF655, DOCK2, XRCC5, PAG1, RACGAP1, MERTK, BLNK, NEK3, AOC3, ARHGDIB, DNM
    Protein Size: 845
    Molekulargewicht
    98 kDa
    Gen-ID
    7409
    NCBI Accession
    NM_005428, NP_005419
    UniProt
    P15498
    Pathways
    T-Zell Rezeptor Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, CXCR4-mediated Signaling Events, BCR Signaling
Sie sind hier:
Kundenservice