MAPK14 Antikörper (C-Term)

Produktnummer ABIN2792183

Produktdetails anti-MAPK14 Antikörper

Target: MAPK14 (Mitogen-Activated Protein Kinase 14 (MAPK14))

Bindungsspezifität: C-Term

Reaktivität: Human, Maus, Ratte, Kaninchen, Rind (Kuh), Schwein, Schaf, Pferd

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MAPK14 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Sequenz: YHDPDDEPVA DPYDQSFESR DLLIDEWKSL TYDEVISFVP PPLDQEEMES

Homologie: Cow: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%, Sheep: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against MAPK14. It was validated on Western Blot and immunohistochemistry.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human MAPK14

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 360 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu MAPK14

Target: MAPK14 (Mitogen-Activated Protein Kinase 14 (MAPK14))

Andere Bezeichnung: MAPK14 (MAPK14 Produkte)

Hintergrund: MAPK14 encodes a protein which is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response.
Alias Symbols: RK, p38, CSBP, EXIP, Mxi2, CSBP1, CSBP2, CSPB1, PRKM14, PRKM15, SAPK2A, p38ALPHA
Protein Interaction Partner: MAPKAPK2, ATF2, PDX1, UBC, MARCKSL1, MAP2K3, MAPK14, ATF6, TCEAL1, USP11, PTPN11, OXCT1, NME1, WDR1, HSPD1, TYMS, ADSS, IQGAP1, MKNK1, MAPKAPK3, CNBP, AKT1, CCDC8, OBSL1, RRP1B, RPS6KA4, SRPK1, MAP2K6, MAPK11, NEB, MAZ, MKNK2, EEF2, DUSP9, ZFP36L1, ADRB2,
Protein Size: 360

Molekulargewicht: 41 kDa

Gen-ID: 1432

NCBI Accession: NM_001315, NP_001306

UniProt: Q16539

Pathways: MAPK Signalweg, Neurotrophin Signalübertragung, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Regulation of Muscle Cell Differentiation, Regulation of Cell Size, Hepatitis C, Toll-Like Receptors Cascades, Autophagie, Thromboxane A2 Receptor Signaling, BCR Signaling, S100 Proteine