CDK8 Antikörper (C-Term)

Produktnummer ABIN2792177

Dieses Anti-CDK8-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von CDK8 in WB. Geeignet für Human, Maus, Zebrafisch (Danio rerio), Hund, Pferd, Kaninchen, Rind (Kuh) und Schwein.

Kurzübersicht für CDK8 Antikörper (C-Term) (ABIN2792177)

Target: CDK8 (Cyclin-Dependent Kinase 8 (CDK8))

Reaktivität: Human, Maus, Zebrafisch (Danio rerio), Hund, Pferd, Kaninchen, Rind (Kuh), Schwein

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CDK8 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-CDK8 Antikörper

Bindungsspezifität: C-Term

Sequenz: GLIMTSDYQR SNPHAAYPNP GPSTSQPQSS MGYSATSQQP PQYSHQTHRY

Homologie: Cow: 100%, Dog: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Zebrafish: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against CDK8. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human CDK8

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 464 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu CDK8

Target: CDK8 (Cyclin-Dependent Kinase 8 (CDK8))

Andere Bezeichnung: CDK8

Hintergrund: The protein encoded by CDK8 is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase and its regulatory subunit cyclin C are components of the RNA polymerase II holoenzyme complex, which phosphorylates the carboxy-terminal domain (CTD) of the largest subunit of RNA polymerase II. This kinase has also been shown to regulate transcription by targeting the CDK7/cyclin H subunits of the general transcription initiation factor IIH (TFIIH), thus providing a link between the 'Mediator-like' protein complexes and the basal transcription machinery.
Alias Symbols: K35
Protein Interaction Partner: CCNC, MED18, MED15, MED31, MED4, MED13L, MED16, MED6, MED13, MED12, MED24, MED20, MED7, MED27, MED17, MED23, MED21, MED14, HERC2, MED22, MED1, MED11, MED8, MED30, MED10, MED28, MED29, MED9, HNRNPF, CDK8, ERCC3, CCNH, MED19, TCEA1, MBP, CTD, MED26, POLR2A,
Protein Size: 464

Molekulargewicht: 53 kDa

Gen-ID: 1024

NCBI Accession: NM_001260, NP_001251

UniProt: P49336

Pathways: Zellzyklus, Regulation of Lipid Metabolism by PPARalpha