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MEK2 Antikörper (N-Term)

MAP2K2 Reaktivität: Human, Maus, Ratte, Hund, Meerschweinchen, Rind (Kuh) WB, IHC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN2783572
  • Target Alle MEK2 (MAP2K2) Antikörper anzeigen
    MEK2 (MAP2K2) (Mitogen-Activated Protein Kinase Kinase 2 (MAP2K2))
    Bindungsspezifität
    • 19
    • 16
    • 12
    • 11
    • 7
    • 7
    • 6
    • 6
    • 5
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reaktivität
    • 135
    • 81
    • 46
    • 6
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human, Maus, Ratte, Hund, Meerschweinchen, Rind (Kuh)
    Wirt
    • 109
    • 25
    • 1
    • 1
    Kaninchen
    Klonalität
    • 109
    • 27
    Polyklonal
    Konjugat
    • 72
    • 11
    • 11
    • 10
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser MEK2 Antikörper ist unkonjugiert
    Applikation
    • 110
    • 61
    • 35
    • 23
    • 21
    • 21
    • 19
    • 15
    • 14
    • 10
    • 7
    • 4
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Sequenz
    LARRKPVLPA LTINPTIAEG PSPTSEGASE ANLVDLQKKL EELELDEQQK
    Homologie
    Cow: 93%, Dog: 93%, Guinea Pig: 93%, Human: 100%, Mouse: 100%, Rat: 100%
    Produktmerkmale
    This is a rabbit polyclonal antibody against MAP2K2. It was validated on Western Blot using a cell lysate as a positive control.
    Aufreinigung
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the N terminal region of human MAP2K2
    Top Product
    Discover our top product MAP2K2 Primärantikörper
  • Applikationshinweise
    Optimal working dilutions should be determined experimentally by the investigator.
    Kommentare

    Antigen size: 400 AA

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freeze-thaw cycles.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target
    MEK2 (MAP2K2) (Mitogen-Activated Protein Kinase Kinase 2 (MAP2K2))
    Andere Bezeichnung
    MAP2K2 (MAP2K2 Produkte)
    Synonyme
    CFC4 antikoerper, MAPKK2 antikoerper, MEK2 antikoerper, MKK2 antikoerper, PRKMK2 antikoerper, AA589381 antikoerper, MK2 antikoerper, Prkmk2 antikoerper, ATMKK2 antikoerper, F27B13.50 antikoerper, F27B13_50 antikoerper, MAP KINASE KINASE 1 antikoerper, MAP kinase kinase 2 antikoerper, MK1 antikoerper, map2k2 antikoerper, wu:fa56c06 antikoerper, zgc:123171 antikoerper, zgc:172250 antikoerper, mitogen-activated protein kinase kinase 2 antikoerper, mitogen activated protein kinase kinase 2 antikoerper, MAP kinase kinase 2 antikoerper, mitogen-activated protein kinase kinase 2a antikoerper, mitogen-activated protein kinase kinase 2b antikoerper, MAP2K2 antikoerper, Map2k2 antikoerper, MKK2 antikoerper, map2k2a antikoerper, map2k2b antikoerper
    Hintergrund
    MAP2K2 is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in MAP2K2 gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene.The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
    Alias Symbols: MAPKK2, MEK2, MKK2, PRKMK2
    Protein Interaction Partner: CCNDBP1, RAF1, SUMO2, UBC, EGFR, IQGAP1, NFE2L2, YWHAB, MAPK1, PEX14, BRAF, ARAF, FAM65B, ZNF207, LIG4, MAPK8, WDR83, Ksr1, COPS5, MAP2K1, MEPCE, GRIN1, CNKSR1, LAMTOR3, GRIN2D, RGS12, CASP9, MAPK3, MAP2K2, DUSP3, Flna,
    Protein Size: 400
    Molekulargewicht
    44 kDa
    Gen-ID
    5605
    NCBI Accession
    NM_030662, NP_109587
    UniProt
    P36507
    Pathways
    MAPK Signalweg, RTK Signalweg, Fc-epsilon Rezeptor Signalübertragung, Neurotrophin Signalübertragung, Activation of Innate immune Response, Toll-Like Receptors Cascades, Signaling of Hepatocyte Growth Factor Receptor, BCR Signaling
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