Growth Hormone Receptor Antikörper (C-Term)
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- Target Alle Growth Hormone Receptor (GHR) Antikörper anzeigen
- Growth Hormone Receptor (GHR)
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Bindungsspezifität
- C-Term
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Reaktivität
- Human, Schwein, Pferd, Hund
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser Growth Hormone Receptor Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB)
- Sequenz
- YSLKVDKEYE VRVRSKQRNS GNYGEFSEVL YVTLPQMSQF TCEEDFYFPW
- Homologie
- Dog: 79%, Horse: 79%, Human: 100%, Pig: 79%
- Produktmerkmale
- This is a rabbit polyclonal antibody against GHR. It was validated on Western Blot.
- Aufreinigung
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the C-terminal region of Human GHR
- Top Product
- Discover our top product GHR Primärantikörper
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- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 mg/mL
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- Avoid repeat freeze-thaw cycles.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- Growth Hormone Receptor (GHR)
- Andere Bezeichnung
- GHR (GHR Produkte)
- Synonyme
- GHBP antikoerper, AA986417 antikoerper, GHR/BP antikoerper, GHR antikoerper, ghr antikoerper, ghr.a antikoerper, zgc:162141 antikoerper, growth hormone receptor antikoerper, growth hormone receptor L homeolog antikoerper, growth hormone receptor a antikoerper, GHR antikoerper, Ghr antikoerper, ghr.L antikoerper, ghr antikoerper, ghra antikoerper
- Hintergrund
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This gene encodes a member of the type I cytokine receptor family, which is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature. In humans and rabbits, but not rodents, growth hormone binding protein (GHBP) is generated by proteolytic cleavage of the extracellular ligand-binding domain from the mature growth hormone receptor protein.
Alias Symbols: GHBP
Protein Interaction Partner: FBXW11, JAK2, GHR, GH1, BTRC, UBC, SKP1, SOCS2, STUB1, PTPRH, PTPRB, PTPN13, PTPN9, PTPN3, PTPN2, PTPN1, DUSP7, NCOA6, STAT5B, SOCS3, SOCS1, SGTA, CISH, GRB10, STAT5A, AP2A1, SHC1, TYK2, PTPN6, PTPN11, PRLR, PIK3R1, JAK1, IRS1, GH2, GRB2, STAT3, PLCG1,
Protein Size: 294 - Molekulargewicht
- 32 kDa
- Gen-ID
- 2690
- NCBI Accession
- NM_001242462, NP_001229391
- Pathways
- NF-kappaB Signalweg, JAK-STAT Signalweg, Response to Growth Hormone Stimulus
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