Growth Hormone Receptor Antikörper (C-Term)

Produktnummer ABIN2781773

Der Kaninchen Polyklonal anti-Growth Hormone Receptor Antikörper wird verwendet zum Nachweis von Growth Hormone Receptor in Proben von Human, Pferd, Hund und Schwein. Er wurde validiert für WB.

Kurzübersicht für Growth Hormone Receptor Antikörper (C-Term) (ABIN2781773)

Target: Growth Hormone Receptor (GHR)

Reaktivität: Human, Pferd, Hund, Schwein

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Growth Hormone Receptor Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-Growth Hormone Receptor Antikörper

Bindungsspezifität: C-Term

Verwendungszweck: GHR Antibody - C-terminal region

Sequenz: YSLKVDKEYE VRVRSKQRNS GNYGEFSEVL YVTLPQMSQF TCEEDFYFPW

Homologie: Dog: 79%, Horse: 79%, Human: 100%, Pig: 79%

Produktmerkmale: This is a rabbit polyclonal antibody against GHR. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human GHR

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP44231-100UG

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Details zu Growth Hormone Receptor

Target: Growth Hormone Receptor (GHR)

Andere Bezeichnung: GHR

Hintergrund:

Background Information: This gene encodes a member of the type I cytokine receptor family, which is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature. In humans and rabbits, but not rodents, growth hormone binding protein (GHBP) is generated by proteolytic cleavage of the extracellular ligand-binding domain from the mature growth hormone receptor protein.

Gene Name: growth hormone receptor

Alternative Symbols: GHBP, GHIP

Protein Name: Growth hormone receptor

Molekulargewicht: 32kDa

Gen-ID: 2690

NCBI Accession: NP_001229391

UniProt: P10912

Pathways: NF-kappaB Signalweg, JAK-STAT Signalweg, Response to Growth Hormone Stimulus