SREBF1 Antikörper (N-Term)

Produktnummer ABIN2780569

Dieses Anti-SREBF1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von SREBF1 in WB. Geeignet für Human, Ratte, Maus, Rind (Kuh), Ziege, Pferd, Meerschweinchen, Kaninchen und Hund.

Kurzübersicht für SREBF1 Antikörper (N-Term) (ABIN2780569)

Target: SREBF1 (Sterol Regulatory Element Binding Transcription Factor 1 (SREBF1))

Reaktivität: Human, Ratte, Maus, Rind (Kuh), Ziege, Pferd, Meerschweinchen, Kaninchen, Hund

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SREBF1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-SREBF1 Antikörper

Bindungsspezifität: N-Term

Sequenz: AGRGRANGLD APRAGADRGA MDCTFEDMLQ LINNQDSDFP GLFDPPYAGS

Homologie: Cow: 93%, Dog: 100%, Goat: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against SREBF1. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human SREBF1

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 1177 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu SREBF1

Target: SREBF1 (Sterol Regulatory Element Binding Transcription Factor 1 (SREBF1))

Andere Bezeichnung: SREBF1

Hintergrund: SREBF1is a transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a decamer flanking the low density lipoprotein receptor gene and some genes involved in sterol biosynthesis. The protein is synthesized as a precursor that is attached to the nuclear membrane and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription by binding to the SRE1. Sterols inhibit the cleavage of the precursor, and the mature nuclear form is rapidly catabolized, thereby reducing transcription. The protein is a member of the basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor family. This gene is located within the Smith-Magenis syndrome region on chromosome 17.This gene encodes a transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a decamer flanking the low density lipoprotein receptor gene and some genes involved in sterol biosynthesis. The protein is synthesized as a precursor that is attached to the nuclear membrane and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription by binding to the SRE1. Sterols inhibit the cleavage of the precursor, and the mature nuclear form is rapidly catabolized, thereby reducing transcription. The protein is a member of the basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor family. This gene is located within the Smith-Magenis syndrome region on chromosome 17. Two transcript variants encoding different isoforms have been found for this gene.
Alias Symbols: SREBP1, bHLHd1, SREBP-1c
Protein Interaction Partner: UBC, ERLIN2, FBXW7, SMARCD3, HSP90AA1, SUMO1, ATXN1L, INSIG2, SCAP, ATXN1, LMNA, INSIG1, EGF, SREBF2, SREBF1, ZBTB7A, ZBTB7C, SUMO2, MED6, MED13, MED12, MED24, MED26, MED17, MED23, MED14, USF1, MED1, GSK3B, CREBBP, CDK8, MED25, MED15, MED7, MED21, SIRT1,
Protein Size: 1177

Molekulargewicht: 125 kDa

Gen-ID: 6720

NCBI Accession: NM_001005291, NP_001005291

Pathways: AMPK Signaling, Caspase Kaskade in der Apoptose, Negative Regulation of Hormone Secretion, Regulation of Lipid Metabolism by PPARalpha