TLE1 Antikörper (N-Term)

Produktnummer ABIN2779588

Der Kaninchen Polyklonal anti-TLE1 Antikörper wird verwendet zum Nachweis von TLE1 in Proben von Human, Maus, Ratte, Zebrafisch (Danio rerio), Rind (Kuh), Hund, Meerschweinchen, Pferd und Kaninchen. Er wurde validiert für WB.

Kurzübersicht für TLE1 Antikörper (N-Term) (ABIN2779588)

Target: TLE1 (Transducin-Like Enhancer of Split 1 (E(sp1) Homolog, Drosophila) (TLE1))

Reaktivität: Human, Maus, Ratte, Zebrafisch (Danio rerio), Rind (Kuh), Hund, Meerschweinchen, Pferd, Kaninchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TLE1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-TLE1 Antikörper

Bindungsspezifität: N-Term

Sequenz: RNGPEFSNDI KKRKVDDKDS SHYDSDGDKS DDNLVVDVSN EDPSSPRASP

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 79%

Produktmerkmale: This is a rabbit polyclonal antibody against TLE1. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human TLE1

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 770 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu TLE1

Target: TLE1 (Transducin-Like Enhancer of Split 1 (E(sp1) Homolog, Drosophila) (TLE1))

Andere Bezeichnung: TLE1

Hintergrund: TLE1 is a transcriptional corepressor that binds to a number of transcription factors. TLE1 inhibits NF-kappa-B-regulated gene expression and the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. TLE1 has an unusual function as coactivator for ESRRG.
Alias Symbols: ESG, ESG1, GRG1
Protein Interaction Partner: TLE1, TCF3, TCF4, UBC, SS18, SSX2, HDAC1, EZH2, ATF2, APH1A, LEF1, TLX3, PROP1, HES1, TLX1, HHEX, FOXG1, ESRRG, EN1, tcf7l1a, NOD2, AES, HESX1, GSK3B, GRB7, NUDT21, DAZAP2, KIAA0408, TSC22D1, TK1, SMN1, RAP1B, GADD45A, CSNK2B, RCC1, CDKN1A, BID, BCL2L1, A
Protein Size: 770

Molekulargewicht: 83 kDa

Gen-ID: 7088

NCBI Accession: NM_005077, NP_005068

UniProt: Q04724

Pathways: WNT Signalweg, SARS-CoV-2 Protein Interaktom