CD40 Antikörper (N-Term)

Produktnummer ABIN2777069

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch CD40 in WB. Er zeigt eine Reaktivität gegenüber Human und Kaninchen.

Kurzübersicht für CD40 Antikörper (N-Term) (ABIN2777069)

Target: CD40

Reaktivität: Human, Kaninchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CD40 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-CD40 Antikörper

Bindungsspezifität: N-Term

Sequenz: WNRETHCHQH KYCDPNLGLR VQQKGTSETD TICTCEEGWH CTSEACESCV

Homologie: Human: 100%, Rabbit: 79%

Produktmerkmale: This is a rabbit polyclonal antibody against CD40. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human CD40

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 277 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu CD40

Target: CD40

Andere Bezeichnung: CD40

Hintergrund: CD40 is a member of the TNF-receptor superfamily. This receptor has been found to be essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis.The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been found to be essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
Alias Symbols: Bp50, CDW40, MGC9013, TNFRSF5, p50
Protein Interaction Partner: TRAF2, TRAF3, PIK3R1, CD40LG, BAG3, Otud7b, Birc3, IL4R, TRAF6, TRAF5, TRAF3IP2, MAP3K8, TRAF4, TRAF1, PIK3CA, CBL, BIRC2, CDC40, TANK, HSPA4, NSMAF, XRCC5, HSPA8, TDP2, RIPK2, CAV1, JAK3, XRCC6, MS4A1, SUMO1, SLC30A7, RNF219, UGGT1, ERP44, NCOA6, USP15,
Protein Size: 277

Molekulargewicht: 30 kDa

Gen-ID: 958

NCBI Accession: NM_001250, NP_001241

UniProt: P25942

Pathways: NF-kappaB Signalweg, Cellular Response to Molecule of Bacterial Origin, M Phase, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Cancer Immune Checkpoints