RPS6KB1 Antikörper

Produktnummer ABIN272052

Produktdetails anti-RPS6KB1 Antikörper

Target: RPS6KB1 (Ribosomal Protein S6 Kinase, 70kDa, Polypeptide 1 (RPS6KB1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RPS6KB1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Spezifität: This antibody detects endogenous levels of p70 S6K protein. (region surrounding Pro412)

Kreuzreaktivität (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Reinheit: > 95 % pure by SDS-PAGE

Anwendungsinformationen

Applikationshinweise: ELISA: 1: 10000approx. 1: 20000. IHC: 1: 50approx. 1: 200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.2., 0.09 % sodium azide, 50 % glycerol

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: DO NOT FREEZE!

Lagerung: 4 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C.

Details zu RPS6KB1

Target: RPS6KB1 (Ribosomal Protein S6 Kinase, 70kDa, Polypeptide 1 (RPS6KB1))

Andere Bezeichnung: RPS6KB1 / STK14A (RPS6KB1 Produkte)

Synonyme: PS6K antikoerper, S6K antikoerper, S6K-beta-1 antikoerper, S6K1 antikoerper, STK14A antikoerper, p70 S6KA antikoerper, p70(S6K)-alpha antikoerper, p70-S6K antikoerper, p70-alpha antikoerper, 10539 antikoerper, 7084 antikoerper, CG10539 antikoerper, DS6K antikoerper, Dmel\\CG10539 antikoerper, Dp70S6k antikoerper, Dp70[s6k] antikoerper, Dp70s6k antikoerper, S6k antikoerper, dS6K antikoerper, dS6k antikoerper, dp70[S6k] antikoerper, dp70s6k antikoerper, dps6k antikoerper, ds6k antikoerper, fs(3)07084 antikoerper, l(3)07084 antikoerper, p70 S6K antikoerper, p70/S6K antikoerper, p70S6K antikoerper, p70[S6 kinase] antikoerper, p70[S6K] antikoerper, p70[S6k] antikoerper, p70[S6kinase] antikoerper, p70s6K antikoerper, s6k antikoerper, s6k11 antikoerper, 2610318I15Rik antikoerper, 4732464A07Rik antikoerper, 70kDa antikoerper, AA959758 antikoerper, AI256796 antikoerper, AI314060 antikoerper, p70/85s6k antikoerper, p70s6k antikoerper, p70s6k-A antikoerper, p70-s6k antikoerper, ps6k antikoerper, rps6kb1 antikoerper, rps6kb1-A antikoerper, s6K1 antikoerper, stk14a antikoerper, fc51h01 antikoerper, wu:fc51h01 antikoerper, zgc:55713 antikoerper, ribosomal protein S6 kinase B1 antikoerper, Ribosomal protein S6 kinase antikoerper, ribosomal protein S6 kinase, polypeptide 1 antikoerper, ribosomal protein S6 kinase B1 L homeolog antikoerper, ribosomal protein S6 kinase B1 S homeolog antikoerper, ribosomal protein S6 kinase b, polypeptide 1b antikoerper, RPS6KB1 antikoerper, S6k antikoerper, Rps6kb1 antikoerper, rps6kb1.L antikoerper, rps6kb1.S antikoerper, rps6kb1b antikoerper

Hintergrund: P70 S6 kinase is a mitogen activated Ser/Thr protein kinase that is required for cell growth and G1 cell cycle progression. p70 S6 kinase phosphorylates the S6 protein of the 40S ribosomal subunit and is involved in translational control of 5' oligopyrimidine tract mRNAs. A second isoform, p85 S6 kinase, is derived from the same gene and is identical to p70 S6 kinase except for 23 extra residues at the amino terminus, which encode a nuclear localizing signal. Both isoforms lie on a mitogen activated signaling pathway downstream of phosphoinositide-3 kinase (PI-3K) and the target of rapamycin, FRAP/mTOR, a pathway distinct from the Ras/MAP kinase cascade. The activity of p70 S6 kinase is controlled by multiple phosphorylation events located within the catalytic, linker and pseudosubstrate domains.Synonyms: 70 kDa ribosomal protein S6 kinase 1, Ribosomal protein S6 kinase I, Ribosomal protein S6 kinase beta-1, S6K-beta-1, S6K1, Serine/threonine-protein kinase 14A, p70 S6 kinase alpha, p70 S6K-alpha, p70 S6KA, p70-S6K 1

Molekulargewicht: approx. 59,70,85 kDa

Gen-ID: 6198

NCBI Accession: NP_003152

UniProt: P23443

Pathways: PI3K-Akt Signalweg, RTK Signalweg, AMPK Signaling, Regulation of Cell Size, Skeletal Muscle Fiber Development, Feeding Behaviour, G-protein mediated Events, Smooth Muscle Cell Migration, Interaction of EGFR with phospholipase C-gamma, Warburg Effekt