Bcl-2 Antikörper
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- Target Alle Bcl-2 (BCL2) Antikörper anzeigen
- Bcl-2 (BCL2) (B-Cell CLL/lymphoma 2 (BCL2))
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Reaktivität
- Maus, Ratte
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Wirt
- Maus
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Klonalität
- Monoklonal
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Konjugat
- Dieser Bcl-2 Antikörper ist unkonjugiert
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Applikation
- Flow Cytometry (FACS)
- Aufreinigung
- The antibody was purified by affinity chromatography.
- Klon
- BCL-10C4
- Isotyp
- IgG1 kappa
- Top Product
- Discover our top product BCL2 Primärantikörper
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anti-B-Cell CLL/lymphoma 2 (BCL2) (N-Term) antibody
BCL2 Reaktivität: Human WB, IF, IHC (p), ICC Wirt: Kaninchen Polyclonal unconjugated
anti-B-Cell CLL/lymphoma 2 (BCL2) (AA 2-211) antibodyBCL2 Reaktivität: Human WB, IHC, IP, ICC Wirt: Kaninchen Polyclonal unconjugated
anti-B-Cell CLL/lymphoma 2 (BCL2) (AA 1-100) antibodyBCL2 Reaktivität: Human WB, IF Wirt: Kaninchen Polyclonal unconjugated
anti-B-Cell CLL/lymphoma 2 (BCL2) (AA 101-160) antibodyBCL2 Reaktivität: Human, Maus, Ratte, Kaninchen, Rind (Kuh), Huhn, Bakterien WB, FACS, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) Wirt: Kaninchen Polyclonal unconjugated
anti-B-Cell CLL/lymphoma 2 (BCL2) (AA 75-110) antibodyBCL2 Reaktivität: Human WB, IF, IHC (p) Wirt: Kaninchen Polyclonal RB04684 unconjugated
anti-B-Cell CLL/lymphoma 2 (BCL2) antibodyBCL2 Reaktivität: Human WB, IHC, IP Wirt: Kaninchen Monoclonal unconjugated
anti-B-Cell CLL/lymphoma 2 (BCL2) (AA 2-211) antibodyBCL2 Reaktivität: Human WB, IHC, IP, ICC Wirt: Maus Monoclonal D1 unconjugated
anti-B-Cell CLL/lymphoma 2 (BCL2) (AA 41-54) antibodyBCL2 Reaktivität: Human WB, FACS, IP, IHC (p), ICC, IHC (fro) Wirt: Maus Monoclonal Bcl-2-100 unconjugated
anti-B-Cell CLL/lymphoma 2 (BCL2) (AA 41-54) antibody (PE)BCL2 Reaktivität: Human FACS Wirt: Maus Monoclonal Bcl-2-100 PE
anti-B-Cell CLL/lymphoma 2 (BCL2) antibodyBCL2 Reaktivität: Human WB, IHC, StM Wirt: Kaninchen Monoclonal BCL2-2210R unconjugated Recombinant Antibody
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- Applikationshinweise
- Optimal working dilution should be determined by the investigator.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Konzentration
- 0.5 mg/mL
- Buffer
- phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide at 0.5 mg/mL.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- 4 °C
- Informationen zur Lagerung
- Upon receipt, store undiluted at between 2°C and 8°C.
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- Target
- Bcl-2 (BCL2) (B-Cell CLL/lymphoma 2 (BCL2))
- Andere Bezeichnung
- Bcl-2 (BCL2 Produkte)
- Hintergrund
- Bcl-2 (B-cell leukemia 2) is an apoptotic protein and a member of the Bcl-2 family containing BH1-4 domains. Two reported isoforms exist α=25 kD, β=22 kD. The Bcl-2 protein forms homo- or hetero-dimers with other Bcl-2 family members. Bcl-2 is distributed in the outer mitochondrial membrane, the nuclear envelope, and the endoplasmic reticulum. This protein blocks apoptotic death by controlling mitochondrial membrane permeability. Cleavage of Bcl-2 can convert to pro-apoptotic (by cleavage of BH4 domain). Bcl-2 has been reported to regulate cell cycle progression via ROS. This protein is modified by ASK1/JNK1, PKC, ERKs, and stress-activated kinase phosphorylation and can be ubiquitinated. Bcl-2 has been shown to interact with Apaf-1, Raf-1, TP53BP2, caspase-3, and form heterodimers with Bax, Bad, Bak, Bcl-xL, and Bag-1. Clone BCL/10C4 has been shown to be useful for Western blotting, immunoprecipitation, and immunofluorescence of the mouse and rat Bcl-2 protein.
- Pathways
- MAPK Signalweg, PI3K-Akt Signalweg, Apoptose, Caspase Kaskade in der Apoptose, Regulation of Muscle Cell Differentiation, Cell-Cell Junction Organization, Skeletal Muscle Fiber Development, Autophagie, Smooth Muscle Cell Migration, Negative Regulation of intrinsic apoptotic Signaling
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