FOXO1 Antikörper

Produktnummer ABIN2664978

Produktdetails anti-FOXO1 Antikörper

Target: FOXO1 (Forkhead Box O1 (FOXO1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser FOXO1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Aufreinigung: The antibody was purified by affinity chromatography.

Klon: 2F8B08

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: The antibody solution should be stored undiluted between 2°C and 8°C.

Details zu FOXO1

Target: FOXO1 (Forkhead Box O1 (FOXO1))

Andere Bezeichnung: FOXO1 (FOXO1 Produkte)

Synonyme: FKH1 antikoerper, FKHR antikoerper, FOXO1A antikoerper, FoxO1a.1 antikoerper, foxo1 antikoerper, zgc:153388 antikoerper, Fkhr antikoerper, Foxo1a antikoerper, AI876417 antikoerper, Afxh antikoerper, Fkhr1 antikoerper, fkh1 antikoerper, fkhr antikoerper, foxo1a antikoerper, xFoxO1 antikoerper, FoxO1A antikoerper, foxo1a.2 antikoerper, forkhead box O1 antikoerper, forkhead box O1 a antikoerper, forkhead box O1 L homeolog antikoerper, forkhead box O1 b antikoerper, FOXO1 antikoerper, foxo1a antikoerper, Foxo1 antikoerper, foxo1 antikoerper, foxo1.L antikoerper, foxo1b antikoerper

Hintergrund: FOXO1 is a transcription factor, belonging to the O subfamily of forkhead box-containing proteins. The forkhead proteins are substrates of Akt/PKB and glucocorticoid-induced kinases that mediate insulin signaling. FOXO1 binds to the conserved insulin-responsive elements and acts as a transcriptional activator. The FOXO1 target genes are involved in cell metabolism, growth, and differentiation. Upon insulin stimulation, FOXO1 proteins are phosphorylated by AKT/PKB through the PI3K pathway, resulting in the translocation of FOXO1 proteins from the nucleus to the cytoplasm. The expression of FOXO1 target genes are then inhibited by FOXO1. FOXO1 has been reported to regulate maturation and class-switch recombination of B cells, as well as participating in regulatory T cell function. FOXO1-deficient mice are embryonic lethal, suggesting that FOXO1 has crucial functions in development which cannot be compensated by other FoxO family members.

Pathways: PI3K-Akt Signalweg, Zellzyklus, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Carbohydrate Homeostasis, Chromatin Binding, Regulation of Carbohydrate Metabolic Process, CXCR4-mediated Signaling Events, BCR Signaling