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IRAK4 Antikörper (AA 38-54)

Dieses Anti-IRAK4-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von IRAK4 in WB und IHC. Geeignet für Human und Maus.
Produktnummer ABIN2470125

Kurzübersicht für IRAK4 Antikörper (AA 38-54) (ABIN2470125)

Target

Alle IRAK4 Antikörper anzeigen
IRAK4 (Interleukin-1 Receptor-Associated Kinase 4 (IRAK4))

Reaktivität

  • 110
  • 60
  • 23
  • 15
  • 14
  • 12
  • 4
  • 3
  • 2
  • 2
  • 1
Human, Maus

Wirt

  • 103
  • 15
  • 1
Kaninchen

Klonalität

  • 100
  • 19
Polyklonal

Konjugat

  • 59
  • 6
  • 5
  • 5
  • 4
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser IRAK4 Antikörper ist unkonjugiert

Applikation

  • 110
  • 48
  • 37
  • 26
  • 20
  • 16
  • 16
  • 10
  • 9
  • 8
  • 5
  • 2
  • 2
  • 1
  • 1
Western Blotting (WB), Immunohistochemistry (IHC)
  • Bindungsspezifität

    • 29
    • 16
    • 11
    • 8
    • 8
    • 6
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 38-54

    Aufreinigung

    Protein G Column

    Immunogen

    IRAK4 antibody was raised against amino acids 38 - 54 of IRAK4 (Mouse).

    Isotyp

    IgG
  • Applikationshinweise

    IRAK4 antibody can be used in ELISA, Western Blot, and immunohistochemistry starting at 10 - 20 μg/mL.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Buffer

    PBS, 0.05 % BSA, 0.05 % sodium azide.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Handhabung

    As with all antibodies avoid freeze/thaw cycles.

    Lagerung

    4 °C/-20 °C

    Informationen zur Lagerung

    IRAK4 antibody can be stored short term 4 °C. For long term storage aliquot and store at -20 °C.
  • Target

    IRAK4 (Interleukin-1 Receptor-Associated Kinase 4 (IRAK4))

    Andere Bezeichnung

    IRAK4

    Hintergrund

    IL-1 receptor-associated kinases (IRAKs) are important mediators in the signal transduction of Toll/IL-1 receptor (TIR) family members. The cytoplasmic domains of TIR proteins interact with the adapter protein, MyD88. MyD88 then recruits IRAKs (IRAK-1, -2, and M), which in turn interact with other adapter molecules, such as TRAF6 to activate NF-κ,B and MAPK pathways. Recently, a new member of this family, IRAK-4 has been identified. IRAK-4 may act as an upstream activator of IRAK-1. IRAK-4 is important for LPS activation of TLRS. Mice lacking IRAK-4 are resistant to lethal doses of LPS and are also severely impaired in their responses to viral and bacterial challenges (4, 5). IRAK4, an IRAK type protein kinase, is a signal transducer for the immune response Toll-like receptor and interleukin-1 (IL-1) receptor signaling cascades. IRAK4 has auto- and cross-phosphorylation kinase activity and has been shown to phosphorylate and activate IRAK1. Additionally, IRAK4 interacts with IRAK1 and TRAF6 in an IL-1-dependent manner, and overexpression of IRAK4 can activate NF-kappaB as well as mitogen-activated protein (MAP) kinase pathways. IRAK4 (-/-) mice are resistant to a lethal dose of lipopolysaccharide and are severely impaired in their responses to viral and bacterial challenges. At least two mRNA transcripts have been reported: 3.0- and 4.4-kb. IRAK4, also referrred to as NY-REN-64, was first identified as an anitgen in a screen of renal tumors.

    Gen-ID

    51135

    UniProt

    Q9NWZ3

    Pathways

    NF-kappaB Signalweg, TLR Signalweg, Activation of Innate immune Response, Toll-Like Receptors Cascades
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